Quantification of risk factors for bovine viral diarrhea virus in cattle herds: A systematic search and meta-analysis of observational studies

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Title: Quantification of risk factors for bovine viral diarrhea virus in cattle herds: A systematic search and meta-analysis of observational studies
Authors: Roon, Annika M. VanMercat, MathildeSchaik, Gerdien vanMore, Simon Johnet al.
Permanent link: http://hdl.handle.net/10197/12294
Date: 1-Oct-2020
Online since: 2021-06-25T10:24:52Z
Abstract: Bovine viral diarrhea virus (BVDV) is endemic in many parts of the world, and multiple countries have implemented surveillance activities for disease control or eradication. In such control programs, the disease-free status can be compromised by factors that pose risks for introduction or persistence of the virus. The aim of the present study was to gain a comprehensive overview of possible risk factors for BVDV infection in cattle herds in Europe and to assess their importance. Papers that considered risk factors for BVDV infection in cattle were identified through a systematic search. Further selection of papers eligible for quantitative analysis was performed using a predefined checklist, including (1) appropriate region (i.e., studies performed in Europe), (2) representativeness of the study population, (3) quality of statistical analysis, and (4) availability of sufficient quantitative data. In total, 18 observational studies were selected. Data were analyzed by a random-effects meta-analysis to obtain pooled estimates of the odds of BVDV infection. Meta-analyses were performed on 6 risk factors: herd type, herd size, participation in shows or markets, introduction of cattle, grazing, and contact with other cattle herds on pasture. Significant higher odds were found for dairy herds (odds ratio, OR = 1.63, 95% confidence interval, CI: 1.06–2.50) compared with beef herds, for larger herds (OR = 1.04 for every 10 extra animals in the herd, 95% CI: 1.02–1.06), for herds that participate in shows or markets (OR = 1.45, 95% CI: 1.10–1.91), for herds that introduced cattle into the herd (OR = 1.41, 95% CI: 1.18–1.69), and for herds that share pasture or have direct contact with cattle of other herds at pasture (OR = 1.32, 95% CI: 1.07–1.63). These pooled values must be interpreted with care, as there was a high level of heterogeneity between studies. However, they do give an indication of the importance of the most frequently studied risk factors and can therefore assist in the development, evaluation, and optimization of BVDV control programs.
Funding Details: Dutch Ministry of Agriculture, Nature and Food Quality
European Food Safety Authority
Type of material: Journal Article
Publisher: Elsevier
Journal: Journal of Dairy Science
Volume: 103
Issue: 10
Start page: 9446
End page: 9463
Copyright (published version): 2020 American Dairy Science Association
Keywords: EuropeBovine viral diarrhea virusMeta-analysisReviewRisk factor
DOI: 10.3168/jds.2020-18193
Language: en
Status of Item: Peer reviewed
ISSN: 0022-0302
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Appears in Collections:Veterinary Medicine Research Collection
CVERA Research Collection

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