Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments

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Title: Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments
Authors: European Food Safety Authority (EFSA), Scientific CommitteeMore, Simon JohnBampidis, VasileiosBenford, Diane
Permanent link: http://hdl.handle.net/10197/12296
Date: 18-Aug-2020
Online since: 2021-06-25T11:27:31Z
Abstract: EFSA requested its Scientific Committee to prepare a guidance document on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. The guidance document provides an introduction to epidemiological studies and illustrates the typical biases of the different epidemiological study designs. It describes key epidemiological concepts relevant for evidence appraisal. Regarding study reliability, measures of association, exposure assessment, statistical inferences, systematic error and effect modification are explained. Regarding study relevance, the guidance describes the concept of external validity. The principles of appraising epidemiological studies are illustrated, and an overview of Risk of Bias (RoB) tools is given. A decision tree is developed to assist in the selection of the appropriate Risk of Bias tool, depending on study question, population and design. The customisation of the study appraisal process is explained, detailing the use of RoB tools and assessing the risk of bias in the body of evidence. Several examples of appraising experimental and observational studies using a Risk of Bias tool are annexed to the document to illustrate the application of the approach. This document constitutes a draft that will be applied in EFSA's assessments during a 1-year pilot phase and be revised and complemented as necessary. Before finalisation of the document, a public consultation will be launched.
Type of material: Journal Article
Publisher: Wiley
Journal: EFSA Journal
Volume: 18
Issue: 8
Copyright (published version): 2020 European Food Safety Authority
Keywords: EFSA Scientific CommitteeEvidence appraisalRisk assessmentExposure assesmentHazard characterisation
DOI: 10.2903/j.efsa.2020.6221
Language: en
Status of Item: Peer reviewed
ISSN: 1831-4732
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Appears in Collections:Veterinary Medicine Research Collection
CVERA Research Collection

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