An in vitro-in vivo sequential cascade for the synthesis of iminosugars from aldoses

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Title: An in vitro-in vivo sequential cascade for the synthesis of iminosugars from aldoses
Authors: Kuska, JustynaTaday, FreyaYeow, KathrynRyan, JamesO'Reilly, Elaine
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Date: 15-Jun-2021
Online since: 2021-07-01T10:22:54Z
Abstract: Here, we report a chemoenzymatic approach for the preparation of a small panel of biologically important iminosugars from readily available aldoses. Our approach involves an in vitro transaminase-mediated amination of aldoses in combination with an in vivo selective oxidation of the chemically protected transaminase products, using Gluconobacter oxydans DSM 2003 whole cells. Chemically catalysed deprotection and reduction steps afford a selection of valuable iminocyclitols.
Funding Details: Science Foundation Ireland
Type of material: Journal Article
Publisher: Royal Society of Chemistry
Journal: Catalysis Science & Technology
Copyright (published version): 2021 Royal Society of Chemistry
Keywords: Carbohydrate mimicsBiotransformationsIminosugarsChemo-enzymatic synthesis
DOI: 10.1039/d1cy00698c
Language: en
Status of Item: Peer reviewed
ISSN: 2044-4753
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Appears in Collections:Chemistry Research Collection

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