An in vitro-in vivo sequential cascade for the synthesis of iminosugars from aldoses
Files in This Item:
|Download||Kuska et al. 2021_Open Access Deposit.pdf||613.05 kB||Adobe PDF|
|Title:||An in vitro-in vivo sequential cascade for the synthesis of iminosugars from aldoses||Authors:||Kuska, Justyna; Taday, Freya; Yeow, Kathryn; Ryan, James; O'Reilly, Elaine||Permanent link:||http://hdl.handle.net/10197/12309||Date:||15-Jun-2021||Online since:||2021-07-01T10:22:54Z||Abstract:||Here, we report a chemoenzymatic approach for the preparation of a small panel of biologically important iminosugars from readily available aldoses. Our approach involves an in vitro transaminase-mediated amination of aldoses in combination with an in vivo selective oxidation of the chemically protected transaminase products, using Gluconobacter oxydans DSM 2003 whole cells. Chemically catalysed deprotection and reduction steps afford a selection of valuable iminocyclitols.||Funding Details:||Science Foundation Ireland||Type of material:||Journal Article||Publisher:||Royal Society of Chemistry||Journal:||Catalysis Science & Technology||Copyright (published version):||2021 Royal Society of Chemistry||Keywords:||Carbohydrate mimics; Biotransformations; Iminosugars; Chemo-enzymatic synthesis||DOI:||10.1039/d1cy00698c||Language:||en||Status of Item:||Peer reviewed||ISSN:||2044-4753||This item is made available under a Creative Commons License:||https://creativecommons.org/licenses/by/3.0/ie/|
|Appears in Collections:||Chemistry Research Collection|
Show full item record
If you are a publisher or author and have copyright concerns for any item, please email firstname.lastname@example.org and the item will be withdrawn immediately. The author or person responsible for depositing the article will be contacted within one business day.