Hypoxia: Turning vessels into vassals of cancer immunotolerance

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Title: Hypoxia: Turning vessels into vassals of cancer immunotolerance
Authors: Schito, LuanaRey, Sergio
Permanent link: http://hdl.handle.net/10197/12322
Date: 1-Sep-2020
Online since: 2021-07-12T15:23:50Z
Abstract: Hypoxia is a universal feature of solid cancers caused by a mismatch between cellular oxygen supply and consumption. To meet the increased demand for oxygen, hypoxic cancer cells (CCs) induce a multifaceted process known as angiogenesis, wherein new vessels are formed by the sprouting of pre-existing ones. In addition to providing oxygen for growth and an exit route for dissemination, angiogenic vessels and factors are co-opted by CCs to enable the generation of an immunotolerant, hypoxic tumor microenvironment, leading to therapeutic failure and mortality. In this review, we discuss how hypoxia-inducible factors (HIFs), the mechanistic target of rapamycin (mTOR), and the unfolded protein response (UPR) control angiogenic factors serving both vascular and immunomodulatory functions in the tumor microenvironment. Possible therapeutic strategies, wherein targeting oxygen sensing might enhance anti-angiogenic and immunologically-mediated anti-cancer responses, are suggested.
Funding Details: University College Dublin
Type of material: Journal Article
Publisher: Elsevier
Journal: Cancer Letters
Volume: 487
Start page: 74
End page: 84
Copyright (published version): 2020 the Authors
Keywords: AngiogenesisCancerHIFHypoxiaHypoxia-inducible factorsImmunotherapyOxygen sensingTargeted therapyTumor microenvironmentUPRmTOR
DOI: 10.1016/j.canlet.2020.05.015
Language: en
Status of Item: Peer reviewed
ISSN: 0304-3835
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by/3.0/ie/
Appears in Collections:Conway Institute Research Collection
Medicine Research Collection

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