Hypoxia: Turning vessels into vassals of cancer immunotolerance
|Title:||Hypoxia: Turning vessels into vassals of cancer immunotolerance||Authors:||Schito, Luana; Rey, Sergio||Permanent link:||http://hdl.handle.net/10197/12322||Date:||1-Sep-2020||Online since:||2021-07-12T15:23:50Z||Abstract:||Hypoxia is a universal feature of solid cancers caused by a mismatch between cellular oxygen supply and consumption. To meet the increased demand for oxygen, hypoxic cancer cells (CCs) induce a multifaceted process known as angiogenesis, wherein new vessels are formed by the sprouting of pre-existing ones. In addition to providing oxygen for growth and an exit route for dissemination, angiogenic vessels and factors are co-opted by CCs to enable the generation of an immunotolerant, hypoxic tumor microenvironment, leading to therapeutic failure and mortality. In this review, we discuss how hypoxia-inducible factors (HIFs), the mechanistic target of rapamycin (mTOR), and the unfolded protein response (UPR) control angiogenic factors serving both vascular and immunomodulatory functions in the tumor microenvironment. Possible therapeutic strategies, wherein targeting oxygen sensing might enhance anti-angiogenic and immunologically-mediated anti-cancer responses, are suggested.||Funding Details:||University College Dublin||Type of material:||Journal Article||Publisher:||Elsevier||Journal:||Cancer Letters||Volume:||487||Start page:||74||End page:||84||Copyright (published version):||2020 the Authors||Keywords:||Angiogenesis; Cancer; HIF; Hypoxia; Hypoxia-inducible factors; Immunotherapy; Oxygen sensing; Targeted therapy; Tumor microenvironment; UPR; mTOR||DOI:||10.1016/j.canlet.2020.05.015||Language:||en||Status of Item:||Peer reviewed||ISSN:||0304-3835||This item is made available under a Creative Commons License:||https://creativecommons.org/licenses/by/3.0/ie/|
|Appears in Collections:||Conway Institute Research Collection|
Medicine Research Collection
Show full item record
If you are a publisher or author and have copyright concerns for any item, please email firstname.lastname@example.org and the item will be withdrawn immediately. The author or person responsible for depositing the article will be contacted within one business day.