Concentric Annular Liquid-Liquid Phase Separation for Flow Chemistry and Continuous Processing

DC FieldValueLanguage
dc.contributor.authorHarding, Matthew J.-
dc.contributor.authorFeng, Bin-
dc.contributor.authorLopez-Rodriguez, Rafael-
dc.contributor.authorO'Connor, Heather-
dc.contributor.authorDowling, Denis P.-
dc.contributor.authorGibson, Geoff-
dc.contributor.authorGirard, Kevin P.-
dc.contributor.authorFerguson, Steven-
dc.date.accessioned2021-08-19T10:35:13Z-
dc.date.available2021-08-19T10:35:13Z-
dc.date.issued2021-06-24-
dc.identifier.citationReaction Chemistry & Engineeringen_US
dc.identifier.urihttp://hdl.handle.net/10197/12419-
dc.description.abstractA low-cost, modular, robust, and easily customisable continuous liquid-liquid phase separator has been developed that uses a tubular membrane and annular channels to allow high fluidic throughputs while maintaining rapid, surface wetting dominated, phase separation. The system is constructed from standard fluidic tube fittings and allows leak tight connections to be made without the need for adhesives, or O-rings. The units tested in this work have been shown to operate at flow rates of 0.1 – 300 mL/min, with equivalent residence times from 80 to 4 seconds, demonstrating the simplicity of scale-up with these units. Further scale-up to litre per minute scales of operation for single units and tens of litres/minute through limited numbering up should allow these low cost concentric annular tubular membrane separators to be used at continuous production scales for pharmaceutical applications for many solvent systems. In principle this approach may be sufficiently scalable to be utilized in-line, in batch pharmaceutical manufacturing also, through further scale-up and numbering up of units. Several solvent systems with varying interfacial tensions have been investigated, and the critical process parameters affecting successful separation have been identified. An additively manufactured diaphragm based back pressure regulator was also developed and printed in PEEK, allowing highly accurate, adjustable, and chemically compatible pressure control to be accessed at low cost.en_US
dc.description.sponsorshipEnterprise Irelanden_US
dc.description.sponsorshipEuropean Commission - European Regional Development Funden_US
dc.description.sponsorshipScience Foundation Irelanden_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectPharmaceutical manufacturingen_US
dc.subjectChemical manufacturingen_US
dc.subjectPhase separatorsen_US
dc.subjectSurface tensionen_US
dc.subjectFused filament fabricationen_US
dc.titleConcentric Annular Liquid-Liquid Phase Separation for Flow Chemistry and Continuous Processingen_US
dc.typeJournal Articleen_US
dc.statusPeer revieweden_US
dc.identifier.volume6en_US
dc.identifier.issue9en_US
dc.identifier.startpage1635en_US
dc.identifier.endpage1643en_US
dc.identifier.doi10.1039/D1RE00119A-
dc.neeo.contributorHarding|Matthew J.|aut|-
dc.neeo.contributorFeng|Bin|aut|-
dc.neeo.contributorLopez-Rodriguez|Rafael|aut|-
dc.neeo.contributorO'Connor|Heather|aut|-
dc.neeo.contributorDowling|Denis P.|aut|-
dc.neeo.contributorGibson|Geoff|aut|-
dc.neeo.contributorGirard|Kevin P.|aut|-
dc.neeo.contributorFerguson|Steven|aut|-
dc.identifier.grantid16/RC/3872-
dc.identifier.grantid12/RC/2275_P2-
dc.identifier.grantidIP20160474-
dc.rights.licensehttps://creativecommons.org/licenses/by/3.0/ie/en_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:Chemical and Bioprocess Engineering Research Collection
Agriculture and Food Science Research Collection
I-Form Research Collection
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