Influence of molecular weight fractionation on the antimicrobial and anticancer properties of a fucoidan rich-extract from the macroalgae Fucus vesiculosus

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Title: Influence of molecular weight fractionation on the antimicrobial and anticancer properties of a fucoidan rich-extract from the macroalgae Fucus vesiculosus
Authors: Cabral, Eduarda M.Mondala, Julie Rose MaeOliveira, MárciaGarcía-Vaquero, Marcoet al.
Permanent link: http://hdl.handle.net/10197/12494
Date: 1-Sep-2021
Online since: 2021-09-23T14:54:09Z
Abstract: The objective of this study was to investigate the antimicrobial and anticancer properties of a fucoidan extract and subsequent fractions isolated from the macroalgae Fucus vesiculosus. The fractions obtained (>300 kDa, <300 kDa, <100 kDa, <50 kDa and <10 kDa) could inhibit the growth of B. subtilis, E. coli, L. innocua and P. fluorescens when assayed at concentrations between 12,500 and 25,000 ppm. The bacterial growth was monitored by optical density (OD) measurements (600 nm, 24 h) at 30 °C or 37 °C, depending upon on the strain used. The extracted fractions were also tested for cytotoxicity against brain glioblastoma cancer cells using the Alamar Blue assay for 24 h, 48 h and 6 days. The >300 kDa fraction presented the lowest IC50 values (0.052% - 24 h; 0.032% - 6 days). The potential bioactivity of fucoidan as an antimicrobial and anticancer agent was demonstrated in this study. Hence, the related mechanisms of action should be explored in a near future.
Funding Details: European Commission Horizon 2020
Science Foundation Ireland
Funding Details: Spanish Ministry of Science, Innovation and Universities
Type of material: Journal Article
Publisher: Elsevier
Journal: International Journal of Biological Macromolecules
Volume: 186
Start page: 994
End page: 1002
Copyright (published version): 2021 the Authors
Keywords: FucoidanLaminarinWeight fractionationBrown macroalgaeAntimicrobial propertiesAnticancer properties
DOI: 10.1016/j.ijbiomac.2021.06.182
Language: en
Status of Item: Peer reviewed
ISSN: 0141-8130
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by/3.0/ie/
Appears in Collections:Agriculture and Food Science Research Collection

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