A Scalable Continuous Photochemical Process for the Generation of Aminopropylsulfones

DC FieldValueLanguage
dc.contributor.authorBaumann, Marcus-
dc.contributor.authorDi Filippo, Mara-
dc.contributor.authorBonciolini, Stefano-
dc.date.accessioned2021-11-09T15:46:19Z-
dc.date.available2021-11-09T15:46:19Z-
dc.date.copyright2020 The Royal Society of Chemistryen_US
dc.date.issued2020-09-18-
dc.identifier.citationOrganic and Biomolecular Chemistryen_US
dc.identifier.issn1477-0520-
dc.identifier.urihttp://hdl.handle.net/10197/12598-
dc.description.abstractAn efficient continuous photochemical process is presented that delivers a series of novel γ-aminopropylsulfones via a tetrabutylammonium decatungstate (TBADT) catalysed HAT-process. Crucial to this success is the exploitation of a new high-power LED emitting at 365 nm that was found to be superior to an alternative medium-pressure Hg lamp. The resulting flow process enabled the scale-up of this transformation reaching throughputs of 20 mmol h−1 at substrate concentrations up to 500 mM. Additionally, the substrate scope of this transformation was evaluated demonstrating the straightforward incorporation of different amine substituents as well as alkyl appendages next to the sulfone moiety. It is anticipated that this methodology will allow for further exploitations of these underrepresented γ-aminopropylsulfone scaffolds in the future.en_US
dc.description.sponsorshipEuropean Commission - European Regional Development Funden_US
dc.description.sponsorshipScience Foundation Irelanden_US
dc.description.sponsorshipUniversity College Dublinen_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectC-C bond forming processen_US
dc.subjectContinuous photochemical processesen_US
dc.subjectFlow-based synthesisen_US
dc.titleA Scalable Continuous Photochemical Process for the Generation of Aminopropylsulfonesen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactothermarcus.baumann@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume18en_US
dc.identifier.issue9428en_US
dc.identifier.startpage9432en_US
dc.identifier.doi10.1039/D0OB01801E-
dc.neeo.contributorBaumann|Marcus|aut|-
dc.neeo.contributorDi Filippo|Mara|aut|-
dc.neeo.contributorBonciolini|Stefano|aut|-
dc.date.embargo2021-09-18en_US
dc.date.updated2020-09-21T17:55:50Z-
dc.identifier.grantidSF1609-
dc.identifier.grantid18/RI/5702-
dc.identifier.grantid12/RC2275_P2-
dc.identifier.grantidSF106-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:Chemistry Research Collection
Files in This Item:
 File SizeFormat
DownloadOBC 2020 asap.pdf1.04 MBAdobe PDF
Show simple item record

Page view(s)

195
Last Week
4
Last month
20
checked on Jan 22, 2022

Download(s)

24
checked on Jan 22, 2022

Google ScholarTM

Check

Altmetric


If you are a publisher or author and have copyright concerns for any item, please email research.repository@ucd.ie and the item will be withdrawn immediately. The author or person responsible for depositing the article will be contacted within one business day.