Development of a Telescoped Flow Process for the Safe and Effective Generation of Propargylic Amines

Title: Development of a Telescoped Flow Process for the Safe and Effective Generation of Propargylic Amines
Authors: Donnelly, KianZhang, HuanBaumann, Marcus
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Date: 10-Oct-2019
Online since: 2021-11-09T15:54:43Z
Abstract: Propargylic amines are important multifunctional building blocks that are frequently exploited in the synthesis of privileged heterocyclic entities. Herein we report on a novel flow process that achieves the safe and effective on-demand synthesis of propargylic amines in a telescoped manner. This process minimizes exposure to hazardous azide intermediates and renders a streamlined route into these building blocks. The value of this approach is demonstrated by the rapid generation of a small selection of drug-like thiazolines that result from a high-yielding reaction cascade between propargylic amines with different aryl isothiocyanates.
Funding Details: University College Dublin
Type of material: Journal Article
Publisher: MDPI
Journal: Molecules
Volume: 24
Issue: 20
Copyright (published version): 2019 the Authors
Keywords: AzidesBuilding block synthesis.Continuous processFlow chemistryPropargylic aminesAminesAzidesIsothiocyanates
DOI: 10.3390/molecules24203658
Language: en
Status of Item: Peer reviewed
ISSN: 1420-3049
This item is made available under a Creative Commons License:
Appears in Collections:Chemistry Research Collection

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