Development of a Telescoped Flow Process for the Safe and Effective Generation of Propargylic Amines
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|Title:||Development of a Telescoped Flow Process for the Safe and Effective Generation of Propargylic Amines||Authors:||Donnelly, Kian; Zhang, Huan; Baumann, Marcus||Permanent link:||http://hdl.handle.net/10197/12600||Date:||10-Oct-2019||Online since:||2021-11-09T15:54:43Z||Abstract:||Propargylic amines are important multifunctional building blocks that are frequently exploited in the synthesis of privileged heterocyclic entities. Herein we report on a novel flow process that achieves the safe and effective on-demand synthesis of propargylic amines in a telescoped manner. This process minimizes exposure to hazardous azide intermediates and renders a streamlined route into these building blocks. The value of this approach is demonstrated by the rapid generation of a small selection of drug-like thiazolines that result from a high-yielding reaction cascade between propargylic amines with different aryl isothiocyanates.||Funding Details:||University College Dublin||Type of material:||Journal Article||Publisher:||MDPI||Journal:||Molecules||Volume:||24||Issue:||20||Copyright (published version):||2019 the Authors||Keywords:||Azides; Building block synthesis.; Continuous process; Flow chemistry; Propargylic amines; Amines; Azides; Isothiocyanates||DOI:||10.3390/molecules24203658||Language:||en||Status of Item:||Peer reviewed||ISSN:||1420-3049||This item is made available under a Creative Commons License:||https://creativecommons.org/licenses/by/3.0/ie/|
|Appears in Collections:||Chemistry Research Collection|
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