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Integrating continuous flow synthesis with in-line analysis and data generation
Alternative Title
Challenges and Opportunities Arising from Integrating Continuous Flow Synthesis with In-line Analysis and Data Generation
Author(s)
Date Issued
2018-07-31
Date Available
2021-11-09T15:57:44Z
Abstract
Continuous flow synthesis of fine chemicals has successfully advanced from an academic niche area to a rapidly growing field of its own that directly impacts developments and applications in industrial settings. Whilst the numerous advantages of flow over batch processing are widely recognised and have led to a wider uptake of continuous flow synthesis within the community, we have reached a point where continuous flow synthesis has to transition from a stand-alone enabling technology to a readily integrated synthesis concept. Thus it is paramount to embrace a multitude of in-line analysis and purification techniques to not only allow for efficiently telescoped multi-step sequences but ultimately generate bioactivity data concomitantly on newly synthesised entities. This short review summarises the state of the art in this field and presents both challenges and opportunities that arise from this ambitious endeavour.
Sponsorship
University College Dublin
Type of Material
Journal Article
Publisher
Royal Society of Chemistry
Journal
Organic and Biomolecular Chemistry
Volume
16
Issue
33
Start Page
5946
End Page
5954
Copyright (Published Version)
2018 The Royal Society of Chemistry
Language
English
Status of Item
Peer reviewed
ISSN
1477-0520
This item is made available under a Creative Commons License
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36
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