Integrating continuous flow synthesis with in-line analysis and data generation

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Title: Integrating continuous flow synthesis with in-line analysis and data generation
Other Titles: Challenges and Opportunities Arising from Integrating Continuous Flow Synthesis with In-line Analysis and Data Generation
Authors: Baumann, Marcus
Permanent link: http://hdl.handle.net/10197/12601
Date: 31-Jul-2018
Online since: 2021-11-09T15:57:44Z
Abstract: Continuous flow synthesis of fine chemicals has successfully advanced from an academic niche area to a rapidly growing field of its own that directly impacts developments and applications in industrial settings. Whilst the numerous advantages of flow over batch processing are widely recognised and have led to a wider uptake of continuous flow synthesis within the community, we have reached a point where continuous flow synthesis has to transition from a stand-alone enabling technology to a readily integrated synthesis concept. Thus it is paramount to embrace a multitude of in-line analysis and purification techniques to not only allow for efficiently telescoped multi-step sequences but ultimately generate bioactivity data concomitantly on newly synthesised entities. This short review summarises the state of the art in this field and presents both challenges and opportunities that arise from this ambitious endeavour.
Funding Details: University College Dublin
Type of material: Journal Article
Publisher: Royal Society of Chemistry
Journal: Organic and Biomolecular Chemistry
Volume: 16
Issue: 33
Start page: 5946
End page: 5954
Copyright (published version): 2018 The Royal Society of Chemistry
Keywords: Frontal affinity-chromatographyTaming hazardous chemistryDrug discoveryReaction sequencesMixed suspension
DOI: 10.1039/c8ob01437j
Language: en
Status of Item: Peer reviewed
ISSN: 1477-0520
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Appears in Collections:Chemistry Research Collection

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