Integrating continuous flow synthesis with in-line analysis and data generation
|Title:||Integrating continuous flow synthesis with in-line analysis and data generation||Other Titles:||Challenges and Opportunities Arising from Integrating Continuous Flow Synthesis with In-line Analysis and Data Generation||Authors:||Baumann, Marcus||Permanent link:||http://hdl.handle.net/10197/12601||Date:||31-Jul-2018||Online since:||2021-11-09T15:57:44Z||Abstract:||Continuous flow synthesis of fine chemicals has successfully advanced from an academic niche area to a rapidly growing field of its own that directly impacts developments and applications in industrial settings. Whilst the numerous advantages of flow over batch processing are widely recognised and have led to a wider uptake of continuous flow synthesis within the community, we have reached a point where continuous flow synthesis has to transition from a stand-alone enabling technology to a readily integrated synthesis concept. Thus it is paramount to embrace a multitude of in-line analysis and purification techniques to not only allow for efficiently telescoped multi-step sequences but ultimately generate bioactivity data concomitantly on newly synthesised entities. This short review summarises the state of the art in this field and presents both challenges and opportunities that arise from this ambitious endeavour.||Funding Details:||University College Dublin||Type of material:||Journal Article||Publisher:||Royal Society of Chemistry||Journal:||Organic and Biomolecular Chemistry||Volume:||16||Issue:||33||Start page:||5946||End page:||5954||Copyright (published version):||2018 The Royal Society of Chemistry||Keywords:||Frontal affinity-chromatography; Taming hazardous chemistry; Drug discovery; Reaction sequences; Mixed suspension||DOI:||10.1039/c8ob01437j||Language:||en||Status of Item:||Peer reviewed||ISSN:||1477-0520||This item is made available under a Creative Commons License:||https://creativecommons.org/licenses/by-nc-nd/3.0/ie/|
|Appears in Collections:||Chemistry Research Collection|
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