Integrating continuous flow synthesis with in-line analysis and data generation

DC FieldValueLanguage
dc.contributor.authorBaumann, Marcus-
dc.date.accessioned2021-11-09T15:57:44Z-
dc.date.available2021-11-09T15:57:44Z-
dc.date.copyright2018 The Royal Society of Chemistryen_US
dc.date.issued2018-07-31-
dc.identifier.citationOrganic and Biomolecular Chemistryen_US
dc.identifier.issn1477-0520-
dc.identifier.urihttp://hdl.handle.net/10197/12601-
dc.description.abstractContinuous flow synthesis of fine chemicals has successfully advanced from an academic niche area to a rapidly growing field of its own that directly impacts developments and applications in industrial settings. Whilst the numerous advantages of flow over batch processing are widely recognised and have led to a wider uptake of continuous flow synthesis within the community, we have reached a point where continuous flow synthesis has to transition from a stand-alone enabling technology to a readily integrated synthesis concept. Thus it is paramount to embrace a multitude of in-line analysis and purification techniques to not only allow for efficiently telescoped multi-step sequences but ultimately generate bioactivity data concomitantly on newly synthesised entities. This short review summarises the state of the art in this field and presents both challenges and opportunities that arise from this ambitious endeavour.en_US
dc.description.sponsorshipUniversity College Dublinen_US
dc.format.mediumPrint-
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectFrontal affinity-chromatographyen_US
dc.subjectTaming hazardous chemistryen_US
dc.subjectDrug discoveryen_US
dc.subjectReaction sequencesen_US
dc.subjectMixed suspensionen_US
dc.titleIntegrating continuous flow synthesis with in-line analysis and data generationen_US
dc.title.alternativeChallenges and Opportunities Arising from Integrating Continuous Flow Synthesis with In-line Analysis and Data Generationen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactothermarcus.baumann@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume16en_US
dc.identifier.issue33en_US
dc.identifier.startpage5946en_US
dc.identifier.endpage5954en_US
dc.identifier.doi10.1039/c8ob01437j-
dc.neeo.contributorBaumann|Marcus|aut|-
dc.date.updated2020-09-21T18:32:46Z-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:Chemistry Research Collection
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