A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry
|Title:||A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry||Authors:||Baumann, Marcus; Moody, Thomas S.; Smyth, Megan; Wharry, Scott||Permanent link:||http://hdl.handle.net/10197/12604||Date:||10-Jan-2020||Online since:||2021-11-09T16:06:30Z||Abstract:||Continuous flow manufacture is an innovative technology platform, which is gaining momentum within the pharmaceutical industry. The key advantages of continuous flow include faster and safer reactions, which can be more environmentally friendly, smaller footprint, better quality product, and critically, the ability to perform chemistry that is difficult or impossible to do in batch mode. Globally, significant efforts have been made to develop the manufacturing flexibility and robustness of processes used to produce chemicals in a continuous way, yet despite these scientific developments, a major challenge for industry is the established application of flow technology to commercially relevant examples. The identification of opportunities to apply flow solutions to current processes is also critical to the success of this new technology for pharmaceutical and fine chemical companies. This review highlights industrial hurdles and the importance of education and showcases recent (2018-2019) and relevant industrial examples where utilization of flow technology has been successfully performed.||Type of material:||Journal Article||Publisher:||American Chemical Society||Journal:||Organic Process Research and Development||Volume:||24||Issue:||10||Start page:||1802||End page:||1813||Copyright (published version):||2020 American Chemical Society||Keywords:||Flow chemistry; Continuous manufacture; Industrial perspective; Green manufacturing; Electrochemistry; Biocatalysis||DOI:||10.1021/acs.oprd.9b00524||Language:||en||Status of Item:||Peer reviewed||ISSN:||1083-6160||This item is made available under a Creative Commons License:||https://creativecommons.org/licenses/by-nc-nd/3.0/ie/|
|Appears in Collections:||Chemistry Research Collection|
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