A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry

DC FieldValueLanguage
dc.contributor.authorBaumann, Marcus-
dc.contributor.authorMoody, Thomas S.-
dc.contributor.authorSmyth, Megan-
dc.contributor.authorWharry, Scott-
dc.date.accessioned2021-11-09T16:06:30Z-
dc.date.available2021-11-09T16:06:30Z-
dc.date.copyright2020 American Chemical Societyen_US
dc.date.issued2020-01-10-
dc.identifier.citationOrganic Process Research and Developmenten_US
dc.identifier.issn1083-6160-
dc.identifier.urihttp://hdl.handle.net/10197/12604-
dc.description.abstractContinuous flow manufacture is an innovative technology platform, which is gaining momentum within the pharmaceutical industry. The key advantages of continuous flow include faster and safer reactions, which can be more environmentally friendly, smaller footprint, better quality product, and critically, the ability to perform chemistry that is difficult or impossible to do in batch mode. Globally, significant efforts have been made to develop the manufacturing flexibility and robustness of processes used to produce chemicals in a continuous way, yet despite these scientific developments, a major challenge for industry is the established application of flow technology to commercially relevant examples. The identification of opportunities to apply flow solutions to current processes is also critical to the success of this new technology for pharmaceutical and fine chemical companies. This review highlights industrial hurdles and the importance of education and showcases recent (2018-2019) and relevant industrial examples where utilization of flow technology has been successfully performed.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Organic Process Research and Development, copyright © American Chemical Society after peer review. To access the final edited and published work, see http://pubs.acs.org/doi/abs/10.1021/acs.oprd.9b00524.en_US
dc.subjectFlow chemistryen_US
dc.subjectContinuous manufactureen_US
dc.subjectIndustrial perspectiveen_US
dc.subjectGreen manufacturingen_US
dc.subjectElectrochemistryen_US
dc.subjectBiocatalysisen_US
dc.titleA Perspective on Continuous Flow Chemistry in the Pharmaceutical Industryen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactothermarcus.baumann@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume24en_US
dc.identifier.issue10en_US
dc.identifier.startpage1802en_US
dc.identifier.endpage1813en_US
dc.identifier.doi10.1021/acs.oprd.9b00524-
dc.neeo.contributorBaumann|Marcus|aut|-
dc.neeo.contributorMoody|Thomas S.|aut|-
dc.neeo.contributorSmyth|Megan|aut|-
dc.neeo.contributorWharry|Scott|aut|-
dc.date.embargo2021-01-10en_US
dc.description.admin2020-10-05 JG: PDF replaced with correct versionen_US
dc.date.updated2020-09-21T18:29:12Z-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
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