Development of a Continuous Flow Photoisomerization Reaction Converting Isoxazoles into Diverse Oxazole Products

DC FieldValueLanguage
dc.contributor.authorBracken, Cormac-
dc.contributor.authorBaumann, Marcus-
dc.date.accessioned2021-11-09T16:08:29Z-
dc.date.available2021-11-09T16:08:29Z-
dc.date.copyright2020 American Chemical Societyen_US
dc.date.issued2020-01-13-
dc.identifier.citationJournal of Organic Chemistryen_US
dc.identifier.issn0022-3263-
dc.identifier.urihttp://hdl.handle.net/10197/12605-
dc.description.abstractA continuous flow process is presented, which directly converts isoxazoles into their oxazole counterparts via a photochemical transposition reaction. This results in the first reported exploitation of this transformation to establish its scope and synthetic utility. A series of various di- and trisubstituted oxazole products bearing different appendages including different heterocyclic moieties were realized through this rapid and mild flow process. Furthermore, the robustness of this approach was demonstrated by generating gram quantities of selected products while also providing insights into likely intermediates.en_US
dc.format.mediumPrint-Electronic-
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © 2020 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.joc.9b03399.en_US
dc.subjectPhotochemical transpositionen_US
dc.subjectRing atomsen_US
dc.subjectRearrangementen_US
dc.titleDevelopment of a Continuous Flow Photoisomerization Reaction Converting Isoxazoles into Diverse Oxazole Productsen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactothermarcus.baumann@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume85en_US
dc.identifier.issue4en_US
dc.identifier.startpage2607en_US
dc.identifier.endpage2617en_US
dc.identifier.doi10.1021/acs.joc.9b03399-
dc.neeo.contributorBracken|Cormac|aut|-
dc.neeo.contributorBaumann|Marcus|aut|-
dc.date.embargo2021-01-13en_US
dc.description.admin2020-10-05 JG: PDF replaced with correct versionen_US
dc.date.updated2020-09-21T17:58:19Z-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
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