Synthesis of Bioderived Cinnolines and Their Flow-Based Conversion into 1,4-Dihydrocinnoline Derivatives

DC FieldValueLanguage
dc.contributor.authorDevlin, Jonathan-
dc.contributor.authorClogher, Richard-
dc.contributor.authorBaumann, Marcus-
dc.date.accessioned2021-11-09T16:11:42Z-
dc.date.available2021-11-09T16:11:42Z-
dc.date.copyright2020 Georg Thieme Verlagen_US
dc.date.issued2020-03-17-
dc.identifier.citationSynletten_US
dc.identifier.issn0936-5214-
dc.identifier.urihttp://hdl.handle.net/10197/12606-
dc.description.abstractStarting from phenylhydrazine and glucose, a versatile cinnoline scaffold was obtained on a multigram scale and further derivatized. A simple continuous-flow hydrogenation process permits the conversion of selected cinnolines into their 1,4-dihydrocinnoline counterparts. These products are generated in high yields and high purities with residence times of less than one minute and, along with their cinnoline precursors, are expected to serve as valuable heterocyclic building blocks for future medicinal chemistry programs.en_US
dc.description.sponsorshipUniversity College Dublinen_US
dc.language.isoenen_US
dc.publisherGeorg Thiemeen_US
dc.subjectFlow synthesisen_US
dc.subjectCinnolinesen_US
dc.subjectDihydrocinnolinesen_US
dc.subjectHydrogenationen_US
dc.subjectOptimizationen_US
dc.subjectThioimidazolesen_US
dc.subjectNitrogenen_US
dc.subjectReactoren_US
dc.subjectDrugsen_US
dc.titleSynthesis of Bioderived Cinnolines and Their Flow-Based Conversion into 1,4-Dihydrocinnoline Derivativesen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactothermarcus.baumann@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume31en_US
dc.identifier.issue5en_US
dc.identifier.startpage487en_US
dc.identifier.endpage491en_US
dc.identifier.doi10.1055/s-0039-1690752-
dc.neeo.contributorDevlin|Jonathan|aut|-
dc.neeo.contributorClogher|Richard|aut|-
dc.neeo.contributorBaumann|Marcus|aut|-
dc.date.embargo2021-03-17en_US
dc.description.admin2020-10-05 JG: PDF replaced with correct versionen_US
dc.date.updated2020-09-21T18:02:55Z-
dc.identifier.grantidSF1606-
dc.identifier.grantidSF1609-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
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