Degradation kinetics of cold plasma-treated antibiotics and their antimicrobial activity

DC FieldValueLanguage
dc.contributor.authorSarangapani, Chaitanya-
dc.contributor.authorZiuzina, Dana-
dc.contributor.authorBehan, Patrice-
dc.contributor.authorBourke, Paula-
dc.contributor.authoret al.-
dc.date.accessioned2021-11-10T17:05:44Z-
dc.date.available2021-11-10T17:05:44Z-
dc.date.copyright2019 the Authorsen_US
dc.date.issued2019-03-08-
dc.identifier.citationScientific Reportsen_US
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10197/12626-
dc.description.abstractAntibiotics, such as ofloxacin (OFX) and ciprofloxacin (CFX), are often detected in considerable concentrations in both wastewater effluents and surface water. This poses a risk to non-target organisms and to human health. The aim of this work was to study atmospheric cold plasma (ACP) degradation of antibiotics in water and meat effluent and to explore any residual antimicrobial activity of samples submitted to the plasma process. The results revealed that ACP successfully degraded the studied antibiotics and that the reaction mechanism is principally related to attack by hydroxyl radicals and ozone. According to the disk diffusion assay, the activity of both antibiotics was considerably reduced by the plasma treatment. However, a microdilution method demonstrated that CFX exhibited higher antimicrobial activity after ACP treatment than the corresponding control revealing a potentially new platform for future research to improve the efficiency of conventional antibiotic treatments. Importantly, short-term exposures to sub-lethal concentrations of the antibiotic equally reduced bacterial susceptibility to both ACP treated and untreated CFX. As a remediation process, ACP removal of antibiotics in complex wastewater effluents is possible. However, it is recommended that plasma encompass degradant structure activity relationships to ensure that biological activity is eliminated against non-target organisms and that life cycle safety of antibiotic compounds is achieved.en_US
dc.description.sponsorshipScience Foundation Irelanden_US
dc.format.mediumElectronic-
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.subjectWaste water treatmenten_US
dc.subjectNonthermal plasmaen_US
dc.subjectTransformation productsen_US
dc.subjectPhotocataluytic degradationen_US
dc.subjectVeterinary antibioticsen_US
dc.subjectComputational evidenceen_US
dc.subjectTreatment plansen_US
dc.subjectOzonationen_US
dc.subjectOzoneen_US
dc.subjectOfloxacinen_US
dc.titleDegradation kinetics of cold plasma-treated antibiotics and their antimicrobial activityen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactotherpaula.bourke@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume9en_US
dc.identifier.issue1en_US
dc.citation.otherArticle Number: 3955en_US
dc.identifier.doi10.1038/s41598-019-40352-9-
dc.neeo.contributorSarangapani|Chaitanya|aut|-
dc.neeo.contributorZiuzina|Dana|aut|-
dc.neeo.contributorBehan|Patrice|aut|-
dc.neeo.contributorBourke|Paula|aut|-
dc.neeo.contributoret al.||aut|-
dc.date.updated2020-09-21T21:20:09Z-
dc.identifier.grantid14/IA/2626(T)-
dc.rights.licensehttps://creativecommons.org/licenses/by/3.0/ie/en_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
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