Distinct chemistries define the diverse biological effects of plasma activated water generated with spark and glow plasma discharges

DC FieldValueLanguage
dc.contributor.authorTsoukou, Evanthia-
dc.contributor.authorDelit, Maxime-
dc.contributor.authorTreint, Louise-
dc.contributor.authorBourke, Paula-
dc.contributor.authorBoehm, Daniela-
dc.date.accessioned2021-11-11T15:36:19Z-
dc.date.available2021-11-11T15:36:19Z-
dc.date.copyright2021 the Authorsen_US
dc.date.issued2021-01-27-
dc.identifier.citationApplied Sciencesen_US
dc.identifier.issn1454-5101-
dc.identifier.urihttp://hdl.handle.net/10197/12647-
dc.description.abstractThe spread of multidrug-resistant bacteria poses a significant threat to human health. Plasma activated liquids (PAL) could be a promising alternative for microbial decontamination, where different PAL can possess diverse antimicrobial efficacies and cytotoxic profiles, depending on the range and concentration of their reactive chemical species. In this research, the biological activity of plasma activated water (PAW) on different biological targets including both microbiological and mammalian cells was investigated in vitro. The aim was to further an understanding of the specific role of distinct plasma reactive species, which is required to tailor plasma activated liquids for use in applications where high antimicrobial activity is required without adversely affecting the biology of eukaryotic cells. PAW was generated by glow and spark discharges, which provide selective generation of hydrogen peroxide, nitrite and nitrate in the liquid. The PAW made by either spark or glow discharges showed similar antimicrobial efficacy and stability of activity, despite the very different reactive oxygen species (ROS) and reactive nitrogen species profiles (RNS). However, different trends were observed for cytotoxic activities and effects on enzyme function, which were translated through the selective chemical species generation. These findings indicate very distinct mechanisms of action which may be exploited when tailoring plasma activated liquids to various applications. A remarkable stability to heat and pressure was noted for PAW generated with this set up, which broadens the application potential. These features also suggest that post plasma modifications and post generation stability can be harnessed as a further means of modulating the chemistry, activity and mode of delivery of plasma functionalised liquids. Overall, these results further understanding on how PAL generation may be tuned to provide candidate disinfectant agents for biomedical application or for bio-decontamination in diverse areas.en_US
dc.description.sponsorshipScience Foundation Irelanden_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectPlasma activated wateren_US
dc.subjectAntibacterial efficacyen_US
dc.subjectStorabilityen_US
dc.subjectTemperature stabilityen_US
dc.subjectCytotoxicityen_US
dc.subjectEnzymatic activityen_US
dc.titleDistinct chemistries define the diverse biological effects of plasma activated water generated with spark and glow plasma dischargesen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactotherpaula.bourke@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume11en_US
dc.identifier.issue3en_US
dc.citation.otherArticle Number: 1178en_US
dc.identifier.doi10.3390/app11031178-
dc.neeo.contributorTsoukou|Evanthia|aut|-
dc.neeo.contributorDelit|Maxime|aut|-
dc.neeo.contributorTreint|Louise|aut|-
dc.neeo.contributorBourke|Paula|aut|-
dc.neeo.contributorBoehm|Daniela|aut|-
dc.date.updated2021-09-29T10:09:25Z-
dc.identifier.grantid15/SIRG/3466-
dc.identifier.grantid16/BBSRC/3391-
dc.identifier.grantid20/US/3678-
dc.rights.licensehttps://creativecommons.org/licenses/by/3.0/ie/en_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:Biosystems and Food Engineering Research Collection
Show simple item record

Page view(s)

126
Last Week
3
Last month
37
checked on Jan 20, 2022

Download(s)

12
checked on Jan 20, 2022

Google ScholarTM

Check

Altmetric


If you are a publisher or author and have copyright concerns for any item, please email research.repository@ucd.ie and the item will be withdrawn immediately. The author or person responsible for depositing the article will be contacted within one business day.