Mechanically evoked cortical potentials: A physiological approach to assessment of anorectal sensory pathways

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dc.contributor.authorCarrington, E. V.-
dc.contributor.authorEvers, Judith-
dc.contributor.authorScott, S. M.-
dc.contributor.authorKnowles, C. H.-
dc.contributor.authorO'Connell, P. R.-
dc.contributor.authorJones, James F. X.- Elsevieren_US
dc.identifier.citationJournal of Neuroscience Methodsen_US
dc.description.abstractBackground: Normal defaecation involves activation of anorectal mechanoreceptors responsive to pressure and stretch. The aim of this study was to develop selective anal and rectal mucosal light-touch stimulation suitable for measurement of cortical evoked potentials (EPs) in order to explore the sensory arm of these pathways. New method: A novel device was manufactured to deliver selective rectal and/or anal light-touch stimulation using a shielded inter-dental brush mounted on a rotating stepper motor (1 Hz, 1 ms, 15° rotation). Resultant somatosensory EPs recorded with a 32-channel cortical multi-electrode array were compared to those elicited by electrical anorectal stimulation (2 mm anal plug electrode [1 Hz, 1 ms, 10 V]). Results: Eighteen anaesthetized female Wistar rats (body mass 180-250 g) were studied. Electrical and mechanical stimulation provoked similar maximal response amplitudes (electrical anorectal 39.0 μV[SEM 5.5], mechanical anal 42.2 μV[8.1], mechanical rectal 45.8 μV[9.0]). Response latency was longer following mechanical stimulation (electrical anorectal 8.8 ms[0.5], mechanical anal 16.4 ms[1.1], mechanical rectal 18.3 ms[2.5]). The extent of activated sensory cortex was smaller for mechanical stimulation. Sensory inferior rectal nerve activity was greater during anal compared to rectal mechanical in a subgroup of 4 rats. Evoked potentials were reproducible over 40 min in a subgroup of 9 rats. Comparison with existing methods: Cortical EPs are typically recorded in response to non-physiological electrical stimuli. The use of a mechanical stimulus may provide a more localized physiological method of assessment. Conclusions: To the authors' knowledge these are the first selective brush-elicited anal and rectal EPs recorded in animals and provide a physiological approach to testing of anorectal afferent pathways.en_US
dc.description.sponsorshipScience Foundation Irelanden_US
dc.rightsThis is the author’s version of a work that was accepted for publication in Journal of Neuroscience Methods. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Neuroscience Methods (256, 2015))
dc.subjectIntestinal mucosaen_US
dc.subjectSomatosensory cortexen_US
dc.subjectWistar ratsen_US
dc.subjectEquipment designen_US
dc.subjectPhysical stimulationen_US
dc.subjectSomatosensory evoked potentialsen_US
dc.subjectElectrical equipment and suppliesen_US
dc.subjectTouch perceptionen_US
dc.subjectThree-dimensional printingen_US
dc.titleMechanically evoked cortical potentials: A physiological approach to assessment of anorectal sensory pathwaysen_US
dc.typeJournal Articleen_US
dc.statusPeer revieweden_US
dc.neeo.contributorCarrington|E. V.|aut|-
dc.neeo.contributorScott|S. M.|aut|-
dc.neeo.contributorKnowles|C. H.|aut|-
dc.neeo.contributorO'Connell|P. R.|aut|-
dc.neeo.contributorJones|James F. X.|aut|-
dc.description.othersponsorshipBowel Disease Research Foundationen_US
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