Acute lumbosacral nerve stimulation does not affect anorectal motor function in a rodent model

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Title: Acute lumbosacral nerve stimulation does not affect anorectal motor function in a rodent model
Authors: Devane, L.Evers, JudithScott, S. M.Knowles, C. H.O'Connell, P. R.Jones, James F. X.
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Date: Mar-2016
Online since: 2021-11-19T16:30:17Z
Abstract: Background: Sacral nerve stimulation has become a first line treatment for fecal incontinence, however, its effect on the motor function of the anorectum is uncertain. The aim of this study was to apply acute lumbosacral nerve stimulation in an animal model and to determine its effect on the external and internal anal sphincter forces, the rectoanal inhibitory and excitatory reflexes, and the slow wave frequency of the internal anal sphincter. Methods: Lumbosacral nerve stimulation was applied to 16 nulliparous female rats. A novel in vivo preparation was designed to allow simultaneous monitoring of external and internal anal sphincter forces. The effect of rectal distension on the two anal sphincters was also studied. Key Results: Lumbosacral nerve stimulation delivered at either S or L in rodents did not affect sphincter forces, rectoanal reflexes or slow wave frequency of anal canal smooth muscle. Conclusions & Inferences: The absence of effect on the motor pathways of continence suggests that the mechanism of action is predominantly on sensory feedback mechanisms from the anorectum, thereby increasing cortical awareness of the pelvic floor.
Funding Details: Science Foundation Ireland
Funding Details: Medtronic
Type of material: Journal Article
Publisher: Wiley
Journal: Neurogastroenterology and Motility
Volume: 28
Issue: 3
Start page: 358
End page: 363
Copyright (published version): 2015 Wiley
Keywords: RectumLumbosacral plexusAnimalsRatsFecal incontinenceAnimal disease modelsElectric stimulationAnal canalFemale
DOI: 10.1111/nmo.12733
Language: en
Status of Item: Peer reviewed
ISSN: 1350-1925
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Appears in Collections:Electrical and Electronic Engineering Research Collection
Medicine Research Collection

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