Acute lumbosacral nerve stimulation does not affect anorectal motor function in a rodent model

DC FieldValueLanguage
dc.contributor.authorDevane, L.-
dc.contributor.authorEvers, Judith-
dc.contributor.authorScott, S. M.-
dc.contributor.authorKnowles, C. H.-
dc.contributor.authorO'Connell, P. R.-
dc.contributor.authorJones, James F. X.-
dc.date.accessioned2021-11-19T16:30:17Z-
dc.date.available2021-11-19T16:30:17Z-
dc.date.copyright2015 Wileyen_US
dc.date.issued2016-03-
dc.identifier.citationNeurogastroenterology and Motilityen_US
dc.identifier.issn1350-1925-
dc.identifier.urihttp://hdl.handle.net/10197/12666-
dc.description.abstractBackground: Sacral nerve stimulation has become a first line treatment for fecal incontinence, however, its effect on the motor function of the anorectum is uncertain. The aim of this study was to apply acute lumbosacral nerve stimulation in an animal model and to determine its effect on the external and internal anal sphincter forces, the rectoanal inhibitory and excitatory reflexes, and the slow wave frequency of the internal anal sphincter. Methods: Lumbosacral nerve stimulation was applied to 16 nulliparous female rats. A novel in vivo preparation was designed to allow simultaneous monitoring of external and internal anal sphincter forces. The effect of rectal distension on the two anal sphincters was also studied. Key Results: Lumbosacral nerve stimulation delivered at either S or L in rodents did not affect sphincter forces, rectoanal reflexes or slow wave frequency of anal canal smooth muscle. Conclusions & Inferences: The absence of effect on the motor pathways of continence suggests that the mechanism of action is predominantly on sensory feedback mechanisms from the anorectum, thereby increasing cortical awareness of the pelvic floor.en_US
dc.description.sponsorshipScience Foundation Irelanden_US
dc.format.mediumPrint-Electronic-
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsThis is the peer reviewed version of the following article: Devane, L.A., Evers, J., Scott, M.S., Knowles, C.H., O'Connell, P. and Jones, J.F.X. (2016), Acute lumbosacral nerve stimulation does not affect anorectal motor function in a rodent model. Neurogastroenterol. Motil., 28: 358-363., which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/nmo.12733. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.subjectRectumen_US
dc.subjectLumbosacral plexusen_US
dc.subjectAnimalsen_US
dc.subjectRatsen_US
dc.subjectFecal incontinenceen_US
dc.subjectAnimal disease modelsen_US
dc.subjectElectric stimulationen_US
dc.subjectAnal canalen_US
dc.subjectFemaleen_US
dc.titleAcute lumbosacral nerve stimulation does not affect anorectal motor function in a rodent modelen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactotherjudith.evers@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume28en_US
dc.identifier.issue3en_US
dc.identifier.startpage358en_US
dc.identifier.endpage363en_US
dc.identifier.doi10.1111/nmo.12733-
dc.neeo.contributorDevane|L.|aut|-
dc.neeo.contributorEvers|Judith|aut|-
dc.neeo.contributorScott|S. M.|aut|-
dc.neeo.contributorKnowles|C. H.|aut|-
dc.neeo.contributorO'Connell|P. R.|aut|-
dc.neeo.contributorJones|James F. X.|aut|-
dc.description.othersponsorshipMedtronicen_US
dc.date.updated2021-05-13T14:00:55Z-
dc.identifier.grantid11/RFP.1/NES/3115-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
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