Options
Impact of intentional weight loss on diabetic kidney disease
Date Issued
2019-10
Date Available
2021-11-24T16:20:13Z
Abstract
Type 2 diabetes mellitus (T2DM) and obesity constitute interwoven pandemics challenging healthcare systems in developed countries, where diabetic kidney disease (DKD) is the most common cause of end-stage renal disease. Obesity accelerates renal functional decline in people with T2DM. Intentional weight loss (IWL) strategies in this population hold promise as a means of arresting DKD progression. In the present paper, we summarize the impact of IWL strategies (stratified by lifestyle intervention, medications, and metabolic surgery) on renal outcomes in obese people with DKD. We reviewed the Medline, EMBASE and Cochrane databases for relevant randomized control trials and observational studies published between August 1, 2018 and April 15, 2019. We found that IWL improves renal outcomes in the setting of DKD and obesity. Rate of progression of DKD slows with IWL, but varying outcome measures among studies makes direct comparison difficult. Furthermore, established means of estimating renal function are imperfect owing to loss of lean muscle mass with IWL strategies. The choice of optimal IWL strategy needs to be individualized; future work should establish the comparative efficacy of IWL strategies in obese people with DKD to better inform such decisions.
Sponsorship
Health Research Board
Health Service Executive
Wellcome Trust
Other Sponsorship
Social Care, Research and Development Division, Northern Ireland
Type of Material
Journal Article
Publisher
Wiley
Journal
Diabetes, Obesity and Metabolism
Volume
21
Issue
10
Start Page
2338
End Page
2341
Copyright (Published Version)
2019 Wiley
Language
English
Status of Item
Peer reviewed
ISSN
1462-8902
This item is made available under a Creative Commons License
File(s)
Owning collection
Scopus© citations
9
Acquisition Date
Mar 28, 2024
Mar 28, 2024
Views
521
Last Month
1
1
Acquisition Date
Mar 28, 2024
Mar 28, 2024
Downloads
74
Last Week
2
2
Last Month
2
2
Acquisition Date
Mar 28, 2024
Mar 28, 2024