Impact of bariatric surgery on cardiovascular and renal complications of diabetes: a focus on clinical outcomes and putative mechanisms

DC FieldValueLanguage
dc.contributor.authorMartin, William P.-
dc.contributor.authorDocherty, Neil G.-
dc.contributor.authorle Roux, Carel W.-
dc.date.accessioned2021-11-29T11:28:30Z-
dc.date.available2021-11-29T11:28:30Z-
dc.date.copyright2018 Taylor & Francisen_US
dc.date.issued2018-09-19-
dc.identifier.citationExpert Review of Endocrinology and Metabolismen_US
dc.identifier.issn1744-6651-
dc.identifier.urihttp://hdl.handle.net/10197/12673-
dc.description.abstractIntroduction: Cardiovascular and renal disease accounts for a substantial proportion of the morbidity and mortality associated with obesity and type 2 diabetes mellitus (T2DM). Bariatric surgery is associated with improved long-term cardiovascular and renal outcomes. Areas covered: All major case-control, cohort, and randomized controlled trial studies of bariatric surgery in adults with T2DM were screened and data on prespecified cardiovascular and renal outcomes collated. Bariatric surgery reduces all-cause mortality and risk of cardiovascular disease, albuminuria and progressive chronic kidney disease. Patients with poorer glycemic control and established microvascular disease preoperatively may stand to benefit the most from the surgical approach. Reduced sympathetic drive, remission of glomerular hypertension, enhanced natriuresis, gut microbiota shifts, reduced systemic and renal inflammation, improved lipoprotein profiles, and reductions in chronic cardiac remodeling may all be implicated. Expert commentary: Ongoing RCTs of bariatric surgery selectively recruiting patients with class 1 obesity and established microvascular complications of diabetes will help to better characterize which subgroups of patients benefit most from this effective therapy.en_US
dc.description.sponsorshipHealth Research Boarden_US
dc.description.sponsorshipHealth Service Executiveen_US
dc.description.sponsorshipWellcome Trusten_US
dc.format.mediumPrint-Electronic-
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.rightsThis is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Endocrinology and Metabolism on 19 September 2018, available online: http://www.tandfonline.com/10.1080/17446651.2018.1518130.en_US
dc.subjectDiabetic nephropathiesen_US
dc.subjectDiabetic angiopathiesen_US
dc.subjectDiabetes Mellitus, Type 2en_US
dc.subjectObesityen_US
dc.subjectBariatric Surgeryen_US
dc.subjectHumansen_US
dc.titleImpact of bariatric surgery on cardiovascular and renal complications of diabetes: a focus on clinical outcomes and putative mechanismsen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactotherwilliam.martin@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume13en_US
dc.identifier.issue5en_US
dc.identifier.startpage251en_US
dc.identifier.endpage262en_US
dc.identifier.doi10.1080/17446651.2018.1518130-
dc.neeo.contributorMartin|William P.|aut|-
dc.neeo.contributorDocherty|Neil G.|aut|-
dc.neeo.contributorle Roux|Carel W.|aut|-
dc.description.admin2020-12-15 JG: 'Track changes' and other markup removed from .docx; converted to PDF. Additional data files left as-isen_US
dc.date.updated2020-10-20T20:00:03Z-
dc.identifier.grantid203930/B/16/Z-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:Conway Institute Research Collection
Medicine Research Collection
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