Comment on: Metabolic surgery improves renal injury independent of weight loss: a meta-analysis

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Title: Comment on: Metabolic surgery improves renal injury independent of weight loss: a meta-analysis
Other Titles: Weight-independent reductions in proteinuria after metabolic surgery: implications for therapy development and treatment algorithms in diabetic kidney disease
Authors: Martin, William P.le Roux, Carel W.
Permanent link: http://hdl.handle.net/10197/12674
Date: 1-Jun-2019
Online since: 2021-11-29T11:40:39Z
Abstract: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and significantly elevates cardiovascular disease risk [1]. Persons with DKD accounted for 45.4% and 38.2% of incident and prevalent cases of end-stage renal disease in the United States in 2015, respectively [2]. Current management of DKD focuses on control of hyperglycemia and hypertension along with renin-angiotensin-aldosterone system blockade to minimize proteinuria. The most notable recent advances in DKD care include sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 agonists, which reduce glycosylated hemoglobin (A1C), blood pressure, weight, cardiovascular mortality, and nephropathy progression [ 3]. Despite this, existing therapies for DKD slow the rate of renal functional decline rather than reversing it.
Funding Details: Health Research Board
Wellcome Trust
Type of material: Journal Article
Publisher: Elsevier
Journal: Surgery for Obesity and Related Diseases
Volume: 15
Issue: 6
Start page: 1020
End page: 1023
Copyright (published version): 2019 American Society for Bariatric Surgery
Keywords: KidneyHumansMorbid obesityWeight lossBariatric Surgery
DOI: 10.1016/j.soard.2019.04.001
Language: en
Status of Item: Peer reviewed
ISSN: 1550-7289
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Appears in Collections:Conway Institute Research Collection
Medicine Research Collection

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