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Comment on: Metabolic surgery improves renal injury independent of weight loss: a meta-analysis
Alternative Title
Weight-independent reductions in proteinuria after metabolic surgery: implications for therapy development and treatment algorithms in diabetic kidney disease
Author(s)
Date Issued
2019-06-01
Date Available
2021-11-29T11:40:39Z
Abstract
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and significantly elevates cardiovascular disease risk [1]. Persons with DKD accounted for 45.4% and 38.2% of incident and prevalent cases of end-stage renal disease in the United States in 2015, respectively [2]. Current management of DKD focuses on control of hyperglycemia and hypertension along with renin-angiotensin-aldosterone system blockade to minimize proteinuria. The most notable recent advances in DKD care include sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 agonists, which reduce glycosylated hemoglobin (A1C), blood pressure, weight, cardiovascular mortality, and nephropathy progression [ 3]. Despite this, existing therapies for DKD slow the rate of renal functional decline rather than reversing it.
Sponsorship
Health Research Board
Wellcome Trust
Type of Material
Journal Article
Publisher
Elsevier
Journal
Surgery for Obesity and Related Diseases
Volume
15
Issue
6
Start Page
1020
End Page
1023
Copyright (Published Version)
2019 American Society for Bariatric Surgery
Language
English
Status of Item
Peer reviewed
ISSN
1550-7289
This item is made available under a Creative Commons License
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