Protocol for a preclinical systematic review and meta-analysis of pharmacological targeting of peroxisome proliferator-activated receptors in experimental renal injury

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Title: Protocol for a preclinical systematic review and meta-analysis of pharmacological targeting of peroxisome proliferator-activated receptors in experimental renal injury
Authors: Martin, William P.Chuah, Yeong H. D.Conroy, EmerReynolds, AlisonJudge, ConorLópez-Hernández, Francisco J.le Roux, Carel W.Docherty, Neil G.
Permanent link: http://hdl.handle.net/10197/12676
Date: 15-Nov-2021
Online since: 2021-11-29T12:00:02Z
Abstract: Introduction Impaired lipid metabolism in the renal tubule plays a prominent role in the progression of renal fibrosis following acute kidney injury (AKI) and in chronic kidney disease (CKD). Peroxisome proliferator-activated receptors (PPARs) are promising druggable targets to mitigate renal fibrosis by redirecting metabolism, including restoration of fatty acid oxidation (FAO) capacity. We aim to synthesise evidence from preclinical studies of pharmacological PPAR targeting in experimental renal injury, and inform the design of future studies evaluating PPAR-mediated restoration of FAO in AKI and CKD.
Funding Details: Health Research Board
Wellcome Trust
Funding Details: Wellcome Trust/ Health Research Board
Type of material: Journal Article
Publisher: BMJ
Journal: BMJ Open Science
Volume: 5
Issue: 1
Copyright (published version): 2021 the Authors
Keywords: PreclinicalRenal injuryChronic kidney diseaseAcute kidney injuryFatty acid oxidationPeroxisome proliferator-activated receptor
DOI: 10.1136/bmjos-2021-100240
Language: en
Status of Item: Peer reviewed
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by/3.0/ie/
Appears in Collections:Conway Institute Research Collection
Conway Institute Research Collection
Medicine Research Collection
Veterinary Medicine Research Collection

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