Impact of Metabolic Surgery on Renal Injury in Pre-Clinical Models of Diabetic Kidney Disease

DC FieldValueLanguage
dc.contributor.authorMartin, William P.-
dc.contributor.authorle Roux, Carel W.-
dc.contributor.authorDocherty, Neil G.-
dc.date.accessioned2021-11-29T12:33:38Z-
dc.date.available2021-11-29T12:33:38Z-
dc.date.copyright2020 Kargeren_US
dc.date.issued2021-11-
dc.identifier.citationNephronen_US
dc.identifier.issn1660-8151-
dc.identifier.urihttp://hdl.handle.net/10197/12678-
dc.description.abstractBackground: Surgical approaches to the treatment of obesity and type 2 diabetes, most notably the Roux-en-Y gastric bypass (RYGB) procedure, have been shown to be renoprotective, reducing the incidence of albuminuria and end-stage kidney disease over 15- to 20-year follow-up in patients with obesity. The tissue level effects of metabolic surgery on the diabetic kidney are not easily interrogated in clinical samples. However, elucidation of the cellular and molecular basis for the renoprotective effects of metabolic surgery is now emerging from a body of pre-clinical work in rodent models of diabetic kidney disease (DKD). Summary: Experimental metabolic surgery (RYGB, sleeve gastrectomy [SG], Roux-en-Y oesophagojejunostomy, and duodenojejunal bypass) exerts a pronounced albuminuria-lowering effect in rat models of DKD. Following RYGB in the Zucker diabetic fatty rat, glomerular histology is improved as demonstrated by reductions in podocyte stress, glomerulomegaly, and glomerulosclerosis. Glomerular ultrastructure improves after RYGB and after SG, manifested by quantifiable reductions in podocyte foot process effacement. The transcriptional programme underpinning these structural improvements has been characterized at the pathway level using RNA sequencing and is associated with a significant reduction in the activation of inflammatory and fibrotic responses. Key Messages: Experimental metabolic surgery reduces biochemical, histological, and molecular indices of DKD. These pre-clinical data support a growing interest in the potential utility of metabolic surgery as a therapeutic approach to slow renal functional decline in patients with obesity and DKD.en_US
dc.description.sponsorshipWellcome Trusten_US
dc.format.mediumPrint-Electronic-
dc.language.isoenen_US
dc.publisherKargeren_US
dc.subjectObesityen_US
dc.subjectType 2 diabetesen_US
dc.subjectDiabetic kidney diseaseen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectAlbuminuriaen_US
dc.subjectMetabolic surgeryen_US
dc.subjectZucker diabetic fatty ratsen_US
dc.titleImpact of Metabolic Surgery on Renal Injury in Pre-Clinical Models of Diabetic Kidney Diseaseen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactotherwilliam.martin@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume145en_US
dc.identifier.issue6en_US
dc.identifier.startpage585en_US
dc.identifier.endpage595en_US
dc.identifier.doi10.1159/000511790-
dc.neeo.contributorMartin|William P.|aut|-
dc.neeo.contributorle Roux|Carel W.|aut|-
dc.neeo.contributorDocherty|Neil G.|aut|-
dc.date.updated2021-11-19T10:24:14Z-
dc.identifier.grantid203930/B/16/Z-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
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