Bacterial Cholangitis in Autosomal Dominant Polycystic Kidney and Liver Disease

DC FieldValueLanguage
dc.contributor.authorMartin, William P.-
dc.contributor.authorVaughan, Lisa E.-
dc.contributor.authorYoshida, Kotaro-
dc.contributor.authoret al.-
dc.date.accessioned2021-11-29T12:57:46Z-
dc.date.available2021-11-29T12:57:46Z-
dc.date.copyright2019 Mayo Foundation for Medical Education and Researchen_US
dc.date.issued2019-06-
dc.identifier.citationMayo Clinic Proceedingsen_US
dc.identifier.issn2542-4548-
dc.identifier.urihttp://hdl.handle.net/10197/12679-
dc.description.abstractTo describe first episodes of bacterial cholangitis complicating autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (ADPLD) and to identify risk factors for cholangitis episodes among patients with ADPKD-associated polycystic liver disease (PLD). We searched the electronic medical records at our tertiary referral center for episodes of cholangitis in patients with ADPKD or ADPLD from January 1, 1996, through June 30, 2017. Cases were categorized as suspected or definite cholangitis by expert review. Clinical, laboratory, and radiologic data were manually abstracted. A nested case-control study was conducted to investigate risk factors for cholangitis in patients with ADPKD. We identified 29 cases of definite or suspected cholangitis complicating PLD (24 with ADPKD-associated PLD and 5 with ADPLD). Among patients with definite cholangitis in ADPKD-associated PLD (n=19) vs ADPLD (n=4), the mean ± SD age was 62.4±12.2 vs 55.1±8.6 years, and 9 (47.4%) vs 0 (0%), respectively, were male. The odds of gallstones (odds ratio [OR], 21.6; 95% CI, 3.17-927; P<.001), prior cholecystectomy (OR, 12.2; 95% CI, 1.59-552; P=.008), duodenal diverticulum (OR, 13.5; 95% CI, 2.44 to not estimable; P=.004), type 2 diabetes mellitus (OR, 6.41; 95% CI, 1.01 to not estimable; P=.05), prior endoscopic retrograde cholangiopancreatography (OR, 14.0; 95% CI, 1.80-631; P=.005), and prior kidney transplant (OR, 8.06; 95% CI, 1.72-76.0; P=.004) were higher in patients with ADPKD-associated PLD with definite cholangitis compared to controls. Gallstones, prior cholecystectomy, duodenal diverticulosis, type 2 diabetes mellitus, prior endoscopic retrograde cholangiopancreatography, and prior kidney transplant constituted risk factors for cholangitis among patients with ADPKD-associated PLD.en_US
dc.format.mediumElectronic-eCollection-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectPolycystic liver diseaseen_US
dc.subjectHepatic cystsen_US
dc.subjectIntrahepatic bile duct dilatationen_US
dc.subjectRecurrent cholangitisen_US
dc.titleBacterial Cholangitis in Autosomal Dominant Polycystic Kidney and Liver Diseaseen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactotherwilliam.martin@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume3en_US
dc.identifier.issue2en_US
dc.identifier.startpage149en_US
dc.identifier.endpage159en_US
dc.identifier.doi10.1016/j.mayocpiqo.2019.03.004-
dc.neeo.contributorMartin|William P.|aut|-
dc.neeo.contributorVaughan|Lisa E.|aut|-
dc.neeo.contributorYoshida|Kotaro|aut|-
dc.neeo.contributoret al.||aut|-
dc.date.updated2021-11-19T10:26:16Z-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
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