Influence of Referral to a Combined Diabetology and Nephrology Clinic on Renal Functional Trends and Metabolic Parameters in Adults With Diabetic Kidney Disease

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dc.contributor.authorMartin, William P.-
dc.contributor.authorGriffin, Tomás P.-
dc.contributor.authorLappin, David W.-
dc.contributor.authorO'Brien, Timothy-
dc.contributor.authorGriffin, Matthew-
dc.contributor.authoret al.-
dc.date.accessioned2021-11-29T13:09:46Z-
dc.date.available2021-11-29T13:09:46Z-
dc.date.copyright2017 Mayo Foundation for Medical Education and Researchen_US
dc.date.issued2017-09-
dc.identifier.citationMayo Clinic Proceedingsen_US
dc.identifier.issn2542-4548-
dc.identifier.urihttp://hdl.handle.net/10197/12680-
dc.description.abstractTo examine the impact of a diabetes renal clinic (DRC) on renal functional and metabolic indices in adults who have diabetes mellitus (DM) and chronic kidney disease (CKD).All patients evaluated at a DRC in a single tertiary referral center from January 1, 2008, to December 31, 2012, were identified. Serial renal and metabolic indices from January 1, 2004, to December 31, 2014, were recorded, and trends over time were analyzed by linear mixed-effects models.A total of 200 patients who had DM and CKD were identified and subdivided into 3 categories based on presumptive CKD etiology: 43 (21.5%) with type 1 DM (T1D) only, 127 (63.5%) with type 2 DM (T2D) only, and 30 (15.0%) with DM and an additional CKD etiology. Average annual absolute (mL/min per body surface area per year) and percentage (%/year) changes, respectively, in Chronic Kidney Disease Epidemiology Collaboration estimated glomerular filtration rate before vs after first DRC attendance were: -1.59 vs -3.10 (P=.31) and -1.22 vs -9.39 (P=.06) for T1D; -5.64 vs -3.07 (P=.004) and -10.88 vs -9.94 (P=.70) for T2D; and -6.50 vs +0.91 (P<.001) and -13.28 vs -2.29 (P=.001) for DM with an additional CKD etiology. Glycemic control worsened in those who had T2D, whereas trends in total cholesterol levels improved in those who had T1D.After first DRC attendance, the absolute rate of estimated glomerular filtration rate decline remained similar for those who had T1D, but it slowed for those who had T2D or DM with additional CKD etiology. Thus, benefits of combined diabetology and nephrology consultation may vary for different diabetic subpopulations.en_US
dc.description.sponsorshipEuropean Commission Horizon 2020en_US
dc.description.sponsorshipEuropean Commission - Seventh Framework Programme (FP7)en_US
dc.description.sponsorshipEuropean Research Councilen_US
dc.description.sponsorshipScience Foundation Ireland -- replaceen_US
dc.format.mediumElectronic-eCollection-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectChronic kidney diseaseen_US
dc.subjectDiabetic kidney diseaseen_US
dc.subjectDiabetes mellitusen_US
dc.titleInfluence of Referral to a Combined Diabetology and Nephrology Clinic on Renal Functional Trends and Metabolic Parameters in Adults With Diabetic Kidney Diseaseen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactotherwilliam.martin@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume1en_US
dc.identifier.issue2en_US
dc.identifier.startpage150en_US
dc.identifier.endpage160en_US
dc.identifier.doi10.1016/j.mayocpiqo.2017.07.003-
dc.neeo.contributorMartin|William P.|aut|-
dc.neeo.contributorGriffin|Tomás P.|aut|-
dc.neeo.contributorLappin|David W.|aut|-
dc.neeo.contributorO'Brien|Timothy|aut|-
dc.neeo.contributorGriffin|Matthew|aut|-
dc.neeo.contributoret al.||aut|-
dc.description.othersponsorshipCollege of Medicine, Nursing and Health Sciences, National University of Ireland, Galwayen_US
dc.date.updated2021-11-19T10:27:08Z-
dc.identifier.grantid634086-
dc.identifier.grantid602470-
dc.identifier.grantid09/ SRC-B1794-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:Conway Institute Research Collection
Medicine Research Collection
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