Spatiotemporally Resolved Heat Dissipation in 3D Patterned Magnetically Responsive Hydrogels

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Title: Spatiotemporally Resolved Heat Dissipation in 3D Patterned Magnetically Responsive Hydrogels
Authors: Monks, PatriciaWychowaniec, Jacek K.McKiernan, EoinClerkin, ShaneCrean, JohnRodriguez, Brian J.Reynaud, Emmanuel G.Heise, AndreasBrougham, Dermot F.
Permanent link: http://hdl.handle.net/10197/12737
Date: 4-Feb-2021
Online since: 2022-01-17T14:17:23Z
Abstract: Multifunctional nanocomposites that exhibit well-defined physical properties and encode spatiotemporally controlled responses are emerging as components for advanced responsive systems, for example, in soft robotics or drug delivery. Here an example of such a system, based on simple magnetic hydrogels composed of iron oxide magnetic nanoflowers and Pluronic F127 that generates heat upon alternating magnetic field irradiation is described. Rules for heat-induction in bulk hydrogels and the heat-dependence on particle concentration, gel volume, and gel exposed surface area are established, and the dependence on external environmental conditions in “closed” as compared to “open” (cell culture) system, with controllable heat jumps, of ∆T 0–12°C, achieved within ≤10 min and maintained described. Furthermore the use of extrusion-based 3D printing for manipulating the spatial distribution of heat in well-defined printed features with spatial resolution <150 µm, sufficiently fine to be of relevance to tissue engineering, is presented. Finally, localized heat induction in printed magnetic hydrogels is demonstrated through spatiotemporally-controlled release of molecules (in this case the dye methylene blue). The study establishes hitherto unobserved control over combined spatial and temporal induction of heat, the applications of which in developing responsive scaffold remodeling and cargo release for applications in regenerative medicine are discussed.
Funding Details: Enterprise Ireland
Science Foundation Ireland
Type of material: Journal Article
Publisher: Wiley
Journal: Small
Volume: 17
Issue: 5
Copyright (published version): 2020 Wiley
Keywords: HydrogelsTissue engineeringNanocompositesHot temperatureThree-dimensional printing
DOI: 10.1002/smll.202004452
Language: en
Status of Item: Peer reviewed
ISSN: 1613-6810
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Appears in Collections:Conway Institute Research Collection
Physics Research Collection
Biomolecular and Biomedical Science Research Collection
Chemistry Research Collection

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