Exploiting Biocatalysed Processes for Telescoped Curtius Rearrangement Reactions in Flow Mode

DC FieldValueLanguage
dc.contributor.authorLeslie, Alexander-
dc.date.accessioned2022-04-29T16:25:49Z-
dc.date.available2022-04-29T16:25:49Z-
dc.date.copyright2021 the Authoren_US
dc.date.issued2021-
dc.identifier.urihttp://hdl.handle.net/10197/12824-
dc.description.abstractThe Curtius rearrangement of carboxylic acids i in the presence of benzyl alcohol was performed as a continuous flow process, enabling a safer and easier scale-up process. Inline purification processes, involving immobilized CALB and a mixture of A-15/A-21, were exploited to afford clean Cbz-carbamate product ii. An excess of benzyl alcohol was required to drive the reaction to completion. Therefore, immobilized CALB was employed to chemoselectively transform the residual benzyl alcohol into easily separable benzyl butyrate iv. To demonstrate the versatility of the products, the Cbz-carbamate ii was further derivatized into alkylated Cbz-carbamate v and ß- amino acids vi.en_US
dc.language.isoenen_US
dc.publisherUniversity College Dublin. School of Chemistryen_US
dc.subjectCurtius rearrangementen_US
dc.subjectCALBen_US
dc.subjectFlow chemistryen_US
dc.subjectCbz-carbamateen_US
dc.titleExploiting Biocatalysed Processes for Telescoped Curtius Rearrangement Reactions in Flow Modeen_US
dc.typeMaster Thesisen_US
dc.statusPeer revieweden_US
dc.type.qualificationnameM.Sc.en_US
dc.neeo.contributorLeslie|Alexander|aut|-
dc.date.updated2021-12-08en
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
dc.contributor.orcid0000-0002-6890-6023en
dc.type.qualificationnamefreetextMScen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:Chemistry Theses
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