Potential of a fucoidan-rich Ascophyllum nodosum extract to reduce Salmonella shedding and improve gastrointestinal health in weaned pigs naturally infected with Salmonella

Files in This Item:
 File SizeFormat
DownloadVenardou et al. 2022.pdf956.51 kBAdobe PDF
Title: Potential of a fucoidan-rich Ascophyllum nodosum extract to reduce Salmonella shedding and improve gastrointestinal health in weaned pigs naturally infected with Salmonella
Authors: Venardou, BrigkitaO'Doherty, John V.Maher, ShaneRyan, Marion T.Gath, VivianRavindran, RajeevKiely, ClaireRajauria, GauravGarcía-Vaquero, MarcoSweeney, Torres
Permanent link: http://hdl.handle.net/10197/12905
Date: 4-Apr-2022
Online since: 2022-06-03T15:44:23Z
Abstract: Background. Dietary supplementation with a fucoidan-rich Ascophyllum nodosum extract (ANE), possessing an in vitro anti-Salmonella Typhimurium activity could be a promising on-farm strategy to control Salmonella infection in pigs. The objectives of this study were to: 1) evaluate the anti-S. Typhimurium activity of ANE (containing 46.6% fucoidan, 18.6% laminarin, 10.7% mannitol, 4.6% alginate) in vitro, and; 2) compare the effects of dietary supplementation with ANE and Zinc oxide (ZnO) on growth performance, Salmonella shedding and selected gut parameters in naturally infected pigs. This was established post-weaning (newly weaned pig experiment) and following regrouping of post-weaned pigs and experimental re-infection with S. Typhimurium (challenge experiment). Results. In the in vitro assay, increasing ANE concentrations led to a linear reduction in S. Typhimurium counts (P <  0.05). In the newly weaned pig experiment (12 replicates/treatment), high ANE supplementation increased gain to feed ratio, similar to ZnO supplementation, and reduced faecal Salmonella counts on d 21 compared to the low ANE and control groups (P <  0.05). The challenge experiment included thirty-six pigs from the previous experiment that remained on their original dietary treatments (control and high ANE groups with the latter being renamed to ANE group) apart from the ZnO group which transitioned onto a control diet on d 21 (ZnO-residual group). These dietary treatments had no effect on performance, faecal scores, Salmonella shedding or colonic and caecal Salmonella counts (P > 0.05). ANE supplementation decreased the Enterobacteriaceae counts compared to the control. Enterobacteriaceae counts were also reduced in the ZnO-residual group compared to the control (P <  0.05). ANE supplementation decreased the expression of interleukin 22 and transforming growth factor beta 1 in the ileum compared to the control (P <  0.05).
Funding Details: Science Foundation Ireland
Type of material: Journal Article
Publisher: Springer
Journal: Journal of Animal Science and Biotechnology
Volume: 13
Start page: 1
End page: 16
Copyright (published version): 2022 The Authors
Keywords: Ascophyllum nodosumGastrointestinal microbiotaInflammationPigSalmonellaSeaweed extractZinc oxide
DOI: 10.1186/s40104-022-00685-4
Language: en
Status of Item: Peer reviewed
ISSN: 2049-1891
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by/3.0/ie/
Appears in Collections:Agriculture and Food Science Research Collection
Veterinary Medicine Research Collection

Show full item record

Page view(s)

235
Last Week
176
Last month
checked on Jun 25, 2022

Download(s)

23
checked on Jun 25, 2022

Google ScholarTM

Check

Altmetric


If you are a publisher or author and have copyright concerns for any item, please email research.repository@ucd.ie and the item will be withdrawn immediately. The author or person responsible for depositing the article will be contacted within one business day.