The Relationship Between Cortical Activation in Response to Anorectal Stimuli and Continence Behavior in Freely Behaving Rats Before and After Application of Sacral Nerve Stimulation

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Title: The Relationship Between Cortical Activation in Response to Anorectal Stimuli and Continence Behavior in Freely Behaving Rats Before and After Application of Sacral Nerve Stimulation
Other Titles: SNS in freely behaving rats
Authors: Evers, JudithO'Connell, P. R.Jones, James F. X.
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Date: 1-Feb-2022
Online since: 2022-06-28T14:20:57Z
Abstract: Background: Changes in anorectal sensation have been reported in patients with fecal incontinence and there is limited evidence that sacral nerve stimulation can restore normal sensation. Objective: The aims of the present study were to investigate changes in transmission of sensory anorectal stimuli in a rodent model of FI and to study the effects of SNS on defecation behaviour. Design & Interventions: An established model of fecal incontinence using pudendal nerve stretch and compression was used in 16 adult female Wistar rats and followed for 3 weeks: six rats received sacral nerve stimulation for 1 week using an implantable neurostimulator and ten rats had non-functioning ‘dummy’ devices inserted. Five additional rats were sham operated. Anorectal cortical evoked potentials were used as a surrogate marker for anorectal sensory function. Main Outcome Measures: Faecal incontinence index, evoked potential amplitude and latency. Results: Fifty percent of rats showed behavioral signs of FI measured by the Fecal Incontinence Index(>0.20), calculated using the pellet distribution outside the cage’s latrine area. Anorectal evoked potential amplitude was reduced in rats with an fecal incontinence index >0.20(p=0.019). The amplitude of forepaw evoked potentials recorded as a control was not different between groups. Sacral nerve stimulation using the fully implantable device and custom rodent lead was safe and stable during this prospective study. Incontinent rats(N=3) that received sacral nerve stimulation showed an improvement of fecal incontinence indexand an increase of evoked potential amplitude to anorectal stimulation compared to the dummy implant controls (N=5). Limitations: The main limitation is the small number of animals that received sacral nerve stimulation. Conclusions: Chronic sacral nerve stimulation is feasible in rats when miniature telemetric devices are used. Behavioral signs of fecal incontinence were positively correlated with latency of anorectal evoked potentials.
Funding Details: Medtronic Inc.
Type of material: Journal Article
Publisher: Diseases of the Colon and Rectum
Journal: Diseases of the colon and rectum
Volume: 65
Issue: 2
Start page: 284
End page: 294
Keywords: Sacral nerve stimulationRodent modelEvoked potentialsBehaviorFecal incontinence
DOI: 10.1097/DCR.0000000000002038
Language: en
Status of Item: Peer reviewed
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Appears in Collections:Electrical and Electronic Engineering Research Collection

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