The Relationship Between Cortical Activation in Response to Anorectal Stimuli and Continence Behavior in Freely Behaving Rats Before and After Application of Sacral Nerve Stimulation

DC FieldValueLanguage
dc.contributor.authorEvers, Judith-
dc.contributor.authorO'Connell, P. R.-
dc.contributor.authorJones, James F. X.-
dc.date.accessioned2022-06-28T14:20:57Z-
dc.date.available2022-06-28T14:20:57Z-
dc.date.issued2022-02-01-
dc.identifier.citationDiseases of the colon and rectumen_US
dc.identifier.urihttp://hdl.handle.net/10197/12932-
dc.description.abstractBackground: Changes in anorectal sensation have been reported in patients with fecal incontinence and there is limited evidence that sacral nerve stimulation can restore normal sensation. Objective: The aims of the present study were to investigate changes in transmission of sensory anorectal stimuli in a rodent model of FI and to study the effects of SNS on defecation behaviour. Design & Interventions: An established model of fecal incontinence using pudendal nerve stretch and compression was used in 16 adult female Wistar rats and followed for 3 weeks: six rats received sacral nerve stimulation for 1 week using an implantable neurostimulator and ten rats had non-functioning ‘dummy’ devices inserted. Five additional rats were sham operated. Anorectal cortical evoked potentials were used as a surrogate marker for anorectal sensory function. Main Outcome Measures: Faecal incontinence index, evoked potential amplitude and latency. Results: Fifty percent of rats showed behavioral signs of FI measured by the Fecal Incontinence Index(>0.20), calculated using the pellet distribution outside the cage’s latrine area. Anorectal evoked potential amplitude was reduced in rats with an fecal incontinence index >0.20(p=0.019). The amplitude of forepaw evoked potentials recorded as a control was not different between groups. Sacral nerve stimulation using the fully implantable device and custom rodent lead was safe and stable during this prospective study. Incontinent rats(N=3) that received sacral nerve stimulation showed an improvement of fecal incontinence indexand an increase of evoked potential amplitude to anorectal stimulation compared to the dummy implant controls (N=5). Limitations: The main limitation is the small number of animals that received sacral nerve stimulation. Conclusions: Chronic sacral nerve stimulation is feasible in rats when miniature telemetric devices are used. Behavioral signs of fecal incontinence were positively correlated with latency of anorectal evoked potentials.en_US
dc.language.isoenen_US
dc.publisherDiseases of the Colon and Rectumen_US
dc.subjectSacral nerve stimulationen_US
dc.subjectRodent modelen_US
dc.subjectEvoked potentialsen_US
dc.subjectBehavioren_US
dc.subjectFecal incontinenceen_US
dc.titleThe Relationship Between Cortical Activation in Response to Anorectal Stimuli and Continence Behavior in Freely Behaving Rats Before and After Application of Sacral Nerve Stimulationen_US
dc.title.alternativeSNS in freely behaving ratsen_US
dc.typeJournal Articleen_US
dc.statusPeer revieweden_US
dc.identifier.volume65en_US
dc.identifier.issue2en_US
dc.identifier.startpage284en_US
dc.identifier.endpage294en_US
dc.identifier.doi10.1097/DCR.0000000000002038-
dc.neeo.contributorEvers|Judith|aut|-
dc.neeo.contributorO'Connell|P. R.|aut|-
dc.neeo.contributorJones|James F. X.|aut|-
dc.date.embargo2023-02-01en_US
dc.description.othersponsorshipMedtronic Inc.en_US
dc.identifier.grantidNM-3419-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.fulltextWith Fulltext-
item.grantfulltextembargo_20230201-
Appears in Collections:Electrical and Electronic Engineering Research Collection
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