The Potential of Multi-Biomarker Panels in Nutrition Research: Total Fruit Intake as an Example

Files in This Item:
 File SizeFormat
DownloadMcNamara et al 2020.pdf206.91 kBAdobe PDF
Title: The Potential of Multi-Biomarker Panels in Nutrition Research: Total Fruit Intake as an Example
Authors: McNamara, Aoife E.Walton, JanetteFlynn, AlbertNugent, Anne P.McNulty, Breige A.Brennan, Lorraine
Permanent link: http://hdl.handle.net/10197/13013
Date: 14-Jan-2021
Online since: 2022-07-25T14:49:26Z
Abstract: Dietary and food intake biomarkers offer the potential of improving the accuracy of dietary assessment. An extensive range of putative intake biomarkers of commonly consumed foods have been identified to date. As the field of food intake biomarkers progresses toward solving the complexities of dietary habits, combining biomarkers associated with single foods or food groups may be required. The objective of this work was to examine the ability of a multi-biomarker panel to classify individuals into categories of fruit intake. Biomarker data was measured using H NMR spectroscopy in two studies: (1) An intervention study where varying amounts of fruit was consumed and (2) the National Adult Nutrition Survey (NANS). Using data from an intervention study a biomarker panel (Proline betaine, Hippurate, and Xylose) was constructed from three urinary biomarker concentrations. Biomarker cut-off values for three categories of fruit intake were developed. The biomarker sum cut-offs were ≤ 4.766, 4.766–5.976, >5.976 μM/mOsm/kg for <100, 101–160, and >160 g fruit intake. The ability of the biomarker sum to classify individuals into categories of fruit intake was examined in the cross-sectional study (NANS) (N = 565). Examination of results in the cross-sectional study revealed excellent agreement with self-reported intake: a similar number of participants were ranked into each category of fruit intake. The work illustrates the potential of multi-biomarker panels and paves the way forward for further development in the field. The use of such panels may be key to distinguishing foods and adding specificity to the predictions of food intake. 1
Funding Details: European Commission Horizon 2020
Type of material: Journal Article
Publisher: Frontiers Media
Journal: Frontiers in Nutrition
Volume: 7
Copyright (published version): 2021 the Authors
Keywords: Dietary biomarkersNutritionDietary assessmentFood intakeMetabolomicsMulti-biomarker panelVegetable intake
DOI: 10.3389/fnut.2020.577720
Language: en
Status of Item: Peer reviewed
ISSN: 2296-861X
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by/3.0/ie/
Appears in Collections:Conway Institute Research Collection
Institute of Food and Health Research Collection
Agriculture and Food Science Research Collection

Show full item record

Page view(s)

189
checked on Aug 13, 2022

Download(s)

7
checked on Aug 13, 2022

Google ScholarTM

Check

Altmetric


If you are a publisher or author and have copyright concerns for any item, please email research.repository@ucd.ie and the item will be withdrawn immediately. The author or person responsible for depositing the article will be contacted within one business day.