Optimisation of a metabotype approach to deliver targeted dietary advice

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Title: Optimisation of a metabotype approach to deliver targeted dietary advice
Authors: Hillesheim, ElaineRyan, Miriam F.Gibney, Eileen R.Roche, Helen M.Brennan, Lorraine
Permanent link: http://hdl.handle.net/10197/13015
Date: 29-Sep-2020
Online since: 2022-07-25T15:38:18Z
Abstract: Background: Targeted nutrition is defined as dietary advice tailored at a group level. Groups known as metabotypes can be identified based on individual metabolic profiles. Metabotypes have been associated with differential responses to diet, which support their use to deliver dietary advice. We aimed to optimise a metabotype approach to deliver targeted dietary advice by encompassing more specific recommendations on nutrient and food intakes and dietary behaviours. Methods: Participants (n = 207) were classified into three metabotypes based on four biomarkers (triacylglycerol, total cholesterol, HDL-cholesterol and glucose) and using a k-means cluster model. Participants in metabotype-1 had the highest average HDL-cholesterol, in metabotype-2 the lowest triacylglycerol and total cholesterol, and in metabotype-3 the highest triacylglycerol and total cholesterol. For each participant, dietary advice was assigned using decision trees for both metabotype (group level) and personalised (individual level) approaches. Agreement between methods was compared at the message level and the metabotype approach was optimised to incorporate messages exclusively assigned by the personalised approach and current dietary guidelines. The optimised metabotype approach was subsequently compared with individualised advice manually compiled. Results: The metabotype approach comprised advice for improving the intake of saturated fat (69% of participants), fibre (66%) and salt (18%), while the personalised approach assigned advice for improving the intake of folate (63%), fibre (63%), saturated fat (61%), calcium (34%), monounsaturated fat (24%) and salt (14%). Following the optimisation of the metabotype approach, the most frequent messages assigned to address intake of key nutrients were to increase the intake of fruit and vegetables, beans and pulses, dark green vegetables, and oily fish, to limit processed meats and high-fat food products and to choose fibre-rich carbohydrates, low-fat dairy and lean meats (60-69%). An average agreement of 82.8% between metabotype and manual approaches was revealed, with excellent agreements in metabotype-1 (94.4%) and metabotype-3 (92.3%). Conclusions: The optimised metabotype approach proved capable of delivering targeted dietary advice for healthy adults, being highly comparable with individualised advice. The next step is to ascertain whether the optimised metabotype approach is effective in changing diet quality.
Funding Details: European Commission Horizon 2020
European Research Council
Funding Details: Brazilian Federal Agency for Support and Evaluation of Graduate Education
Type of material: Journal Article
Publisher: BMC
Journal: Nutrition and Metabolism
Volume: 17
Issue: 1
Copyright (published version): 2020 the Authors
Keywords: Cluster metabolitesMetabolitesPersonalised nutritionTargeted nutrition
DOI: 10.1186/s12986-020-00499-z
Language: en
Status of Item: Peer reviewed
ISSN: 1743-7075
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by/3.0/ie/
Appears in Collections:Conway Institute Research Collection
Institute of Food and Health Research Collection
Public Health, Physiotherapy and Sports Science Research Collection
Agriculture and Food Science Research Collection

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