Examination of cell-host-biomaterial interactions via high-throughput technologies : a re-appraisal

Files in This Item:
File Description SizeFormat 
Biomaterials_review_2010_KPower.pdf340.88 kBAdobe PDFDownload
Title: Examination of cell-host-biomaterial interactions via high-throughput technologies : a re-appraisal
Authors: Power, Karen Ann
Fitzgerald, Kathleen T.
Gallagher, William M.
Permanent link: http://hdl.handle.net/10197/2424
Date: Sep-2010
Abstract: Biomaterials are required to act harmoniously when exposed to the body or bodily fluids. Investigating cellular or in vivo phenotypic responses and protein adsorption to the material surface helps to determine the associated biocompatibility. Past limitations on progress in this field include time-consuming cell-based screening tools and a limited understanding of the complex nature of cell–biomaterial interactions. While high-throughput technologies by their nature are a rapid tool to derive meaning from multifaceted systems and, in recent years, the biomaterial community is beginning to take advantage of these technologies, the key observation in this Leading Opinion Paper is that the biomaterials community has been slow to accept these methods as an addition to their traditional experimentation workflow. The purpose of this paper is to review the definition and recent usage of high-throughput experiments in order to examine biomaterial interactions at the cellular and wider host level, especially as they become more relevant within the biomaterials arena encapsulating tissue engineering, gene, drug and stem cell delivery systems. The technologies under focus include rapid cell-based screening, transcriptomics and proteomics.
Funding Details: Science Foundation Ireland
Higher Education Authority
Type of material: Review
Publisher: Elsevier
Copyright (published version): 2010 Elsevier Ltd
Keywords: Biocompatibility;Transcriptomics;Proteomics;DNA microarrays;Mass spectrometry;Cell interaction
Subject LCSH: Biocompatibility
DNA microarrays
Proteomics
Cell interaction
DOI: 10.1016/j.biomaterials.2010.05.029
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection

Show full item record

SCOPUSTM   
Citations 10

22
Last Week
0
Last month
checked on Jun 15, 2018

Page view(s) 10

199
checked on May 25, 2018

Download(s) 5

1,071
checked on May 25, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.