Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis

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Title: Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis
Authors: Cotter, John J.
O'Gara, James P.
Mack, Dietrich
Casey, Eoin
Permanent link: http://hdl.handle.net/10197/2744
Date: Jan-2009
Abstract: Using a modified rotating-disk reactor to sparge oxygen to Staphylococcus epidermidis cultures, we found that oxygen negatively regulates biofilm development by influencing the activity of {sigma}B. Under anaerobic conditions, increased {sigma}B activity activates icaADBC, which encodes enzymes responsible for polysaccharide intercellular adhesin synthesis, by repressing transcription of the negative regulator icaR.
Funding Details: Science Foundation Ireland
Type of material: Journal Article
Publisher: ASM
Copyright (published version): 2009, American Society for Microbiology.
Keywords: Biofilm;Oxygen;Staphylococcus;Epidermidis;SigmaB;Polysaccharide intercellular adhesin;icaR
Subject LCSH: Biofilms
Oxygen
Staphylococcus
Cell adhesion molecules
Polysaccharides
DOI: 10.1128/AEM.00261-08
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Chemical and Bioprocess Engineering Research Collection
CSCB Research Collection

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