Genetic channel capacity revisited

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Title: Genetic channel capacity revisited
Authors: Balado, Félix
Permanent link: http://hdl.handle.net/10197/3406
Date: Dec-2011
Abstract: We revisit previous analyses on the computation of the maximum mutual information between a genetic sequence and its mutated versions down the generations, taking into account the protein translation mechanism of the genetic machinery. This amounts to the application of Shannon's capacity to the study of the transmission of genetic information. Studies on this subject were started by Yockey and then followed by a number of researchers. Here we refine prior analyses employing the Kimura model of base substitution mutations, which is more realistic than the Jukes-Cantor model used by all previous research on this topic. Furthermore we undertake exact computations where prior works just used approximations, and we propose two practical applications of genetic capacity.
Funding Details: Science Foundation Ireland
Type of material: Conference Publication
Publisher: Springer
Copyright (published version): 2012, Springer
Keywords: Information theory;Genetic channel capacity
Subject LCSH: Information theory
Molecular genetics
Mutation (Biology)
DOI: 10.1007/978-3-642-32711-7_7
Language: en
Status of Item: Peer reviewed
Is part of: Hart, E. et al. (eds.) Bio-Inspired Models of Networks, Information, and Computing Systems : 6th International ICST Conference, BIONETICS 2011, York, UK, December 5-6, 2011, Revised Selected Papers
Conference Details: Bionetics 2011, 6th International ICST Conference on Bio-Inspired Models of Network, Information, and Computing Systems, 5-6 December 2011, York, England
Appears in Collections:Computer Science Research Collection

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