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Genetic channel capacity revisited
Author(s)
Date Issued
2011-12
Date Available
2011-12-16T12:36:36Z
Abstract
We revisit previous analyses on the computation of the maximum mutual information between a genetic sequence and its mutated versions down the generations, taking into account the protein translation mechanism of the genetic machinery. This amounts to the application of Shannon's capacity to the study of the transmission of genetic information. Studies on this subject were started by Yockey and then followed by a number of researchers. Here we refine prior analyses employing the Kimura model of base substitution mutations, which is more realistic than the Jukes-Cantor model used by all previous research on this topic. Furthermore we undertake exact computations where prior works just used approximations, and we propose two practical applications of genetic capacity.
Sponsorship
Science Foundation Ireland
Type of Material
Conference Publication
Publisher
Springer
Copyright (Published Version)
2012, Springer
Subject – LCSH
Information theory
Molecular genetics
Mutation (Biology)
Language
English
Status of Item
Peer reviewed
Part of
Hart, E. et al. (eds.) Bio-Inspired Models of Networks, Information, and Computing Systems : 6th International ICST Conference, BIONETICS 2011, York, UK, December 5-6, 2011, Revised Selected Papers
Conference Details
Bionetics 2011, 6th International ICST Conference on Bio-Inspired Models of Network, Information, and Computing Systems, 5-6 December 2011, York, England
ISBN
978-3-642-32710-0
This item is made available under a Creative Commons License
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