Quantitative MRI analysis of brain volume changes due to controlled cortical impact
|Title:||Quantitative MRI analysis of brain volume changes due to controlled cortical impact||Authors:||Colgan, Niall C.
Cronin, Michelle M.
Gobbo, Olivier L.
O'Mara, S. M. (Shane M.)
Gilchrist, M. D.
|Permanent link:||http://hdl.handle.net/10197/3531||Date:||26-Jul-2010||Online since:||2012-02-23T12:19:13Z||Abstract:||More than 85% of reported brain traumas are classified clinically as “mild” using GCS; qualitative MRI findings are scarce and provide little correspondence to clinical symptoms. Our goal, therefore, was to establish in-vivo sequellae of traumatic brain injury following lower and higher levels of impact to the frontal lobe using quantitative MRI analysis and a mechanical model of penetrating impact injury. To investigate time-based morphological and physiological changes of living tissue requires a surrogate for the human central nervous system. The present model for TBI was a systematically varied and controlled cortical impact on deeply-anaesthetized Sprague Dawley rats designed to mimic different injury severities. Whole-brain MRI scans were performed on each rat prior to either a lower or a higher level of impact and then at hourly intervals for five hours post-impact. Both brain volume and specific anatomical structures were segmented from MR images for inter-subject comparisons post-registration. Animals subjected to lower and higher impact levels exhibited elevated intracranial pressure (ICP) in the low compensatory reserve (i.e., nearly exhausted) and terminal disturbance (i.e., exhausted) ranges, respectively. There was a statistically-significant drop in cerebrospinal fluid of 35% in the lower impacts and 65% in the higher impacts at Hr5 in comparison to the sham control. There was a corresponding increase in corpus callosum volume starting from Hr1 of 60-110% and 30-40% following the lower and higher impact levels, respectively. A statistically significant change in the abnormal tissue from Hr2 to Hr5 was observed for both impact levels, with greater significance for higher impacts. Furthermore, a statistically significant difference between the lower impacts and the sham controls occurred at Hr3. These results are statistically substantiated by a fluctuation in the physical size of the corpus callosum, a decrease in the volume of CSF, and elevated levels of atrophy in the cerebral cortex.||Funding Details:||Science Foundation Ireland
Higher Education Authority
|Type of material:||Journal Article||Publisher:||Mary Ann Liebert||Journal:||Journal of Neurotrauma||Volume:||27||Issue:||7||Start page:||1265||End page:||1274||Copyright (published version):||Mary Ann Liebert, Inc||Keywords:||Animal studies; MRI; Rat; Traumatic brain injury||Subject LCSH:||Magnetic resonance imaging
Brain damage--Animal models
|DOI:||10.1089/neu.2009.1267||Other versions:||http:/dx.doi.org/10.1089/neu.2009.1267||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Mechanical & Materials Engineering Research Collection|
Biomolecular and Biomedical Science Research Collection
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