Quantitative MRI analysis of brain volume changes due to controlled cortical impact

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Title: Quantitative MRI analysis of brain volume changes due to controlled cortical impact
Authors: Colgan, Niall C.
Cronin, Michelle M.
Gobbo, Olivier L.
O'Mara, S. M. (Shane M.)
O'Connor, William
Gilchrist, M. D.
Permanent link: http://hdl.handle.net/10197/3531
Date: 26-Jul-2010
Online since: 2012-02-23T12:19:13Z
Abstract: More than 85% of reported brain traumas are classified clinically as “mild” using GCS; qualitative MRI findings are scarce and provide little correspondence to clinical symptoms. Our goal, therefore, was to establish in-vivo sequellae of traumatic brain injury following lower and higher levels of impact to the frontal lobe using quantitative MRI analysis and a mechanical model of penetrating impact injury. To investigate time-based morphological and physiological changes of living tissue requires a surrogate for the human central nervous system. The present model for TBI was a systematically varied and controlled cortical impact on deeply-anaesthetized Sprague Dawley rats designed to mimic different injury severities. Whole-brain MRI scans were performed on each rat prior to either a lower or a higher level of impact and then at hourly intervals for five hours post-impact. Both brain volume and specific anatomical structures were segmented from MR images for inter-subject comparisons post-registration. Animals subjected to lower and higher impact levels exhibited elevated intracranial pressure (ICP) in the low compensatory reserve (i.e., nearly exhausted) and terminal disturbance (i.e., exhausted) ranges, respectively. There was a statistically-significant drop in cerebrospinal fluid of 35% in the lower impacts and 65% in the higher impacts at Hr5 in comparison to the sham control. There was a corresponding increase in corpus callosum volume starting from Hr1 of 60-110% and 30-40% following the lower and higher impact levels, respectively. A statistically significant change in the abnormal tissue from Hr2 to Hr5 was observed for both impact levels, with greater significance for higher impacts. Furthermore, a statistically significant difference between the lower impacts and the sham controls occurred at Hr3. These results are statistically substantiated by a fluctuation in the physical size of the corpus callosum, a decrease in the volume of CSF, and elevated levels of atrophy in the cerebral cortex.
Funding Details: Science Foundation Ireland
Higher Education Authority
Other funder
Type of material: Journal Article
Publisher: Mary Ann Liebert
Journal: Journal of Neurotrauma
Volume: 27
Issue: 7
Start page: 1265
End page: 1274
Copyright (published version): Mary Ann Liebert, Inc
Keywords: Animal studiesMRIRatTraumatic brain injury
Subject LCSH: Magnetic resonance imaging
Brain damage--Animal models
DOI: 10.1089/neu.2009.1267
Other versions: http:/dx.doi.org/10.1089/neu.2009.1267
Language: en
Status of Item: Peer reviewed
Appears in Collections:Mechanical & Materials Engineering Research Collection
Biomolecular and Biomedical Science Research Collection

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