Quantitative MRI analysis of brain volume changes due to controlled cortical impact

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dc.contributor.authorColgan, Niall C.-
dc.contributor.authorCronin, Michelle M.-
dc.contributor.authorGobbo, Olivier L.-
dc.contributor.authorO'Mara, S. M. (Shane M.)-
dc.contributor.authorO'Connor, William-
dc.contributor.authorGilchrist, M. D.-
dc.date.copyrightMary Ann Liebert, Incen
dc.identifier.citationJournal of Neurotraumaen
dc.description.abstractMore than 85% of reported brain traumas are classified clinically as “mild” using GCS; qualitative MRI findings are scarce and provide little correspondence to clinical symptoms. Our goal, therefore, was to establish in-vivo sequellae of traumatic brain injury following lower and higher levels of impact to the frontal lobe using quantitative MRI analysis and a mechanical model of penetrating impact injury. To investigate time-based morphological and physiological changes of living tissue requires a surrogate for the human central nervous system. The present model for TBI was a systematically varied and controlled cortical impact on deeply-anaesthetized Sprague Dawley rats designed to mimic different injury severities. Whole-brain MRI scans were performed on each rat prior to either a lower or a higher level of impact and then at hourly intervals for five hours post-impact. Both brain volume and specific anatomical structures were segmented from MR images for inter-subject comparisons post-registration. Animals subjected to lower and higher impact levels exhibited elevated intracranial pressure (ICP) in the low compensatory reserve (i.e., nearly exhausted) and terminal disturbance (i.e., exhausted) ranges, respectively. There was a statistically-significant drop in cerebrospinal fluid of 35% in the lower impacts and 65% in the higher impacts at Hr5 in comparison to the sham control. There was a corresponding increase in corpus callosum volume starting from Hr1 of 60-110% and 30-40% following the lower and higher impact levels, respectively. A statistically significant change in the abnormal tissue from Hr2 to Hr5 was observed for both impact levels, with greater significance for higher impacts. Furthermore, a statistically significant difference between the lower impacts and the sham controls occurred at Hr3. These results are statistically substantiated by a fluctuation in the physical size of the corpus callosum, a decrease in the volume of CSF, and elevated levels of atrophy in the cerebral cortex.en
dc.description.sponsorshipScience Foundation Irelanden
dc.description.sponsorshipHigher Education Authorityen
dc.description.sponsorshipOther funderen
dc.format.extent352518 bytes-
dc.publisherMary Ann Lieberten
dc.relation.requiresBiomolecular and Biomedical Science Research Collectionen
dc.rightsThis is a copy of an article published in the Journal of Neurotrauma © Mary Ann Liebert, Inc. Journal of Neurotrauma is available online at: http://www.liebertonline.com.en
dc.subjectAnimal studiesen
dc.subjectTraumatic brain injuryen
dc.subject.lcshMagnetic resonance imagingen
dc.subject.lcshBrain damage--Animal modelsen
dc.titleQuantitative MRI analysis of brain volume changes due to controlled cortical impacten
dc.typeJournal Articleen
dc.internal.availabilityFull text availableen
dc.statusPeer revieweden
dc.neeo.contributorColgan|Niall C.|aut|-
dc.neeo.contributorCronin|Michelle M.|aut|-
dc.neeo.contributorGobbo|Olivier L.|aut|-
dc.neeo.contributorO'Mara|S. M. (Shane M.)|aut|-
dc.neeo.contributorGilchrist|M. D.|aut|-
dc.description.othersponsorshipEnterprise Irelanden
dc.description.adminti, ke, ab - TS 02.12en
item.fulltextWith Fulltext-
Appears in Collections:Mechanical & Materials Engineering Research Collection
Biomolecular and Biomedical Science Research Collection
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