Alternative mild route to the synthesis of 4-methylenecyclohex-2-enone, a key moiety of the anticancer compounds ottelione A and B
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|Title:||Alternative mild route to the synthesis of 4-methylenecyclohex-2-enone, a key moiety of the anticancer compounds ottelione A and B||Authors:||Lestini, Elena
Murphy, Cormac D.
|Permanent link:||http://hdl.handle.net/10197/3634||Date:||27-Feb-2012||Abstract:||Rare 4-methylenecyclohex-2-enone is prepared from a Diels-Alder methanesulfonate adduct and sodium iodide in acetone in up to 70% yield under mild conditions. This procedure is envisaged to be relevant to the synthesis of 4-methylenecyclo hex-2-enone analogues, structurally similar to the key functionality of cytotoxic otteliones and with potentially significant bioactivity.||Funding Details:||Higher Education Authority||Type of material:||Journal Article||Publisher:||Taylor & Francis||Journal:||Synthetic Communications||Volume:||42||Issue:||12||Start page:||1864||End page:||1876||Copyright (published version):||2012 Taylor & Francis||Keywords:||Otteliones; Danishefsky’s diene; Diels–Alder cycloaddition; 4-methylenecyclohex-2-enone||Subject LCSH:||Antineoplastic agents
Ring formation (Chemistry)
|DOI:||10.1080/00397911.2011.607936||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Chemistry Research Collection|
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