A simple and efficient method for the synthesis of Erlenmeyer azlactones

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Title: A simple and efficient method for the synthesis of Erlenmeyer azlactones
Authors: Conway, Philip A.
Devine, Kevin
Paradisi, Francesca
Permanent link: http://hdl.handle.net/10197/3637
Date: 11-Apr-2009
Abstract: We have recently developed a novel and efficient method for synthesising Erlenmeyer azlactones under mild and rapid conditions. The reaction is performed by reacting 2-phenyl-5-oxazolone with an aldehyde in dichloromethane using alumina as a catalyst. The materials react instantly at room temperature, negating the need for high temperatures and long reaction times. We have successfully used this method for both aliphatic, aromatic and heteroaromatic aldehydes, synthesising previously unmade Erlenmeyer azlactones in moderate to high yields.
Funding Details: Science Foundation Ireland
Type of material: Journal Article
Publisher: Elsevier
Copyright (published version): 2009 Elsevier
Keywords: Aromatic azlactonesAliphatic azlactonessolid-phase catalysis
Subject LCSH: Aromatic compounds
Aliphatic compounds
Solid-phase synthesis
DOI: 10.1016/j.tet.2009.02.011
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

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