A simple and efficient method for the synthesis of Erlenmeyer azlactones

DC FieldValueLanguage
dc.contributor.authorConway, Philip A.-
dc.contributor.authorDevine, Kevin-
dc.contributor.authorParadisi, Francesca-
dc.date.accessioned2012-06-13T13:57:31Z-
dc.date.available2012-06-13T13:57:31Z-
dc.date.copyright2009 Elsevieren
dc.date.issued2009-04-11-
dc.identifier.citationTetrahedronen
dc.identifier.urihttp://hdl.handle.net/10197/3637-
dc.description.abstractWe have recently developed a novel and efficient method for synthesising Erlenmeyer azlactones under mild and rapid conditions. The reaction is performed by reacting 2-phenyl-5-oxazolone with an aldehyde in dichloromethane using alumina as a catalyst. The materials react instantly at room temperature, negating the need for high temperatures and long reaction times. We have successfully used this method for both aliphatic, aromatic and heteroaromatic aldehydes, synthesising previously unmade Erlenmeyer azlactones in moderate to high yields.en
dc.description.sponsorshipScience Foundation Irelanden
dc.format.extent192512 bytes-
dc.format.mimetypeapplication/msword-
dc.language.isoenen
dc.publisherElsevieren
dc.rightsThis is the author’s version of a work that was accepted for publication in Tetrahedron. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron (2009) DOI: 10.1016/j.tet.2009.02.011en
dc.subjectAromatic azlactonesen
dc.subjectAliphatic azlactonesen
dc.subjectsolid-phase catalysisen
dc.subject.lcshAromatic compoundsen
dc.subject.lcshAliphatic compoundsen
dc.subject.lcshSolid-phase synthesisen
dc.titleA simple and efficient method for the synthesis of Erlenmeyer azlactonesen
dc.typeJournal Articleen
dc.internal.availabilityFull text availableen
dc.statusPeer revieweden
dc.identifier.volume65en
dc.identifier.issue15en
dc.identifier.startpage2935en
dc.identifier.endpage2938en
dc.identifier.doi10.1016/j.tet.2009.02.011-
dc.neeo.contributorConway|Philip A.|aut|-
dc.neeo.contributorDevine|Kevin|aut|-
dc.neeo.contributorParadisi|Francesca|aut|-
item.grantfulltextopen-
item.fulltextWith Fulltext-
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