One-step diketopiperazine synthesis using phase transfer catalysis

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Title: One-step diketopiperazine synthesis using phase transfer catalysis
Authors: O'Reilly, Elaine
Lestini, Elena
Balducci, Daniele
Paradisi, Francesca
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Date: 15-Apr-2009
Abstract: A simple and efficient one-step procedure is described for the synthesis of a number of symmetrical 1,4-disubstituted piperazine-2,5-diones under phase transfer conditions. The reactions are carried out at room temperature, starting from a suitable N-chloroacetamide in the presence of an aqueous solution of sodium hydroxide. Piperazine-2,5-diones were obtained with excellent selectivity in yields of up to 90%.
Funding Details: Higher Education Authority
Irish Research Council for Science, Engineering and Technology
Type of material: Journal Article
Publisher: Elsevier
Copyright (published version): 2009 Elsevier
Keywords: DiketopiperazineChloroacetamidePhase transfer catalystTEBA
Subject LCSH: Organic cyclic compounds--Synthesis
Phase-transfer catalysts
DOI: 10.1016/j.tetlet.2009.01.146
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

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