Time and Space Resolved Uptake Study of Silica Nanoparticles by Human Cells
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|Title:||Time and Space Resolved Uptake Study of Silica Nanoparticles by Human Cells||Authors:||Shapero, Kayle
Cottell, David C.
Dawson, Kenneth A.
|Permanent link:||http://hdl.handle.net/10197/3694||Date:||2011||Online since:||2012-06-21T15:38:42Z||Abstract:||A spatio-temporal mapping of the uptake of silica (SiO2) nanoparticles of different sizes by lung epithelial cells has been obtained. Based on high control of nanoparticle dispersion in cell media and cell exposure, one obtains reproducible and quantitative time-resolved data using a combination of flow cytometry, fluorescence and electron microscopies. We are thereby able to give a rather detailed account of the journey of SiO2 nanoparticles from the early events of uptake to their final sub-cellular localization.||Funding Details:||Science Foundation Ireland
Irish Research Council for Science, Engineering and Technology
European Research Council
|Type of material:||Journal Article||Publisher:||Royal Society of Chemistry||Journal:||Molecular Biosystems||Volume:||7||Issue:||2||Start page:||371||End page:||378||Copyright (published version):||The Royal Society of Chemistry 2011||Keywords:||Silica; Nanoparticle uptake; Flow cytometry; Transmission electronmicroscopy||Subject LCSH:||Silica
Transmission electron microscopy
|DOI:||10.1039/C0MB00109K||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Centre for Bionano Interactions (CBNI) Research Collection|
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