Time and Space Resolved Uptake Study of Silica Nanoparticles by Human Cells

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Title: Time and Space Resolved Uptake Study of Silica Nanoparticles by Human Cells
Authors: Shapero, Kayle
Fenaroli, Federico
Lynch, Iseult
Cottell, David C.
Salvati, Anna
Dawson, Kenneth A.
Permanent link: http://hdl.handle.net/10197/3694
Date: 2011
Online since: 2012-06-21T15:38:42Z
Abstract: A spatio-temporal mapping of the uptake of silica (SiO2) nanoparticles of different sizes by lung epithelial cells has been obtained. Based on high control of nanoparticle dispersion in cell media and cell exposure, one obtains reproducible and quantitative time-resolved data using a combination of flow cytometry, fluorescence and electron microscopies. We are thereby able to give a rather detailed account of the journey of SiO2 nanoparticles from the early events of uptake to their final sub-cellular localization.
Funding Details: Science Foundation Ireland
Irish Research Council for Science, Engineering and Technology
European Research Council
Type of material: Journal Article
Publisher: Royal Society of Chemistry
Journal: Molecular Biosystems
Volume: 7
Issue: 2
Start page: 371
End page: 378
Copyright (published version): The Royal Society of Chemistry 2011
Keywords: SilicaNanoparticle uptakeFlow cytometryTransmission electronmicroscopy
Subject LCSH: Silica
Flow cytometry
Transmission electron microscopy
DOI: 10.1039/C0MB00109K
Language: en
Status of Item: Peer reviewed
Appears in Collections:Centre for Bionano Interactions (CBNI) Research Collection

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