Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

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Title: Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum
Authors: Clark, Benjamin R.
Murphy, Cormac D.
Permanent link: http://hdl.handle.net/10197/3699
Date: 2009
Abstract: The biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and [13C]-acetate confirmed that these were the precursors of the pyrrole moiety, methyl groups, and backbone of rumbrin, respectively. Label-dilution experiments with pyrrole-2-carboxylate confirmed it was a direct precursor in the biosynthesis of rumbrin. Both 3- and 4-chloropyrrolecarboxylates were also accepted as precursors in polyene production.
Funding Details: Irish Research Council for Science, Engineering and Technology
Type of material: Journal Article
Publisher: RSC Publishing
Journal: Organic and Biomolecular Chemistry
Volume: 7
Issue: 1
Start page: 111
End page: 116
Copyright (published version): 2009 the authors
Keywords: Polyketide
Subject LCSH: Polyketides--Synthesis
Pyrroles--Synthesis
DOI: 10.1039/B813236D
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection
CSCB Research Collection

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