Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

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Title: Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.
Authors: Moran, Stephen
Rai, Dilip K.
Clark, Benjamin R.
Murphy, Cormac D.
Permanent link: http://hdl.handle.net/10197/3700
Date: 2009
Abstract: Some iturin A-producing strains of Bacillus subtilis will elaborate the novel fluorinated analogue when incubated with 3-fluoro-L-tyrosine. The activity of iturin A is dependent on the D-tyrosine residue and the presence of fluorotyrosine may result in an improvement of the biological properties of this lipopeptide. The fluorinated iturin might also be used as a probe for studying its interaction with biological membranes.
Funding Details: Irish Research Council for Science, Engineering and Technology
Type of material: Journal Article
Publisher: RSC Publishing
Copyright (published version): 2009 the authors
Keywords: Fluorine;Antibiotic
Subject LCSH: Fluorine
Antibiotics--Synthesis
Bacillus subtilis
DOI: 10.1039/b816345f
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection
CSCB Research Collection

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