Novel approach to the synthesis of aliphatic and aromatic alpha-keto acids

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Title: Novel approach to the synthesis of aliphatic and aromatic alpha-keto acids
Authors: Balducci, Daniele
Conway, Philip A.
Sapuppo, Giulia
Müller-Bunz, Helge
Paradisi, Francesca
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Date: Sep-2012
Online since: 2012-08-24T15:44:19Z
Abstract: A new practical and efficient synthesis of alpha-keto acids was accomplished starting from the synthon 1,4-diacetylpiperazine-2,5-dione. The synthesis encompasses both aromatic and aliphatic substrates proving to be versatile and innovative with excellent carbon economy and recycling of the glycine by-product.
Funding Details: Science Foundation Ireland
Higher Education Authority
Type of material: Journal Article
Publisher: Elsevier
Journal: Tetrahedron
Volume: 68
Issue: 36
Start page: 7374
End page: 7379
Copyright (published version): 2012 Elsevier B.V
Keywords: Alpha-keto acidsAliphaticAromaticAldol reaction
Subject LCSH: Ketonic acids--Synthesis
Aliphatic compounds--Synthesis
Aromatic compounds--Synthesis
DOI: 10.1016/j.tet.2012.06.078
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

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