Biotransformation of flurbiprofen by Cunninghamella species

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Title: Biotransformation of flurbiprofen by Cunninghamella species
Authors: Amadio, Jessica
Gordon, Katherine
Murphy, Cormac D.
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Date: Sep-2010
Abstract: The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and di-hydroxylated metabolites were detected using gas chromatography-mass spectrometry and fluorine-19 nuclear magnetic resonance spectroscopy, and the major metabolite 4’-hydroxyflurbiprofen was isolated by preparative HPLC. C. elegans DSM 1908 and C. blakesleeana DSM 1906 also produced a phase II (conjugated) metabolite, which was identified as the sulfated drug via deconjugation experiments.
Funding Details: Other funder
Type of material: Journal Article
Publisher: American Society for Microbiology
Copyright (published version): 2010 American Society for Microbiology
Keywords: Fluorine
Subject LCSH: Anti-inflammatory agents
Biotransformation (Metabolism)
DOI: 10.1128/AEM.01027-10
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection

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