Biotransformation of flurbiprofen by Cunninghamella species
|Title:||Biotransformation of flurbiprofen by Cunninghamella species||Authors:||Amadio, Jessica
Murphy, Cormac D.
|Permanent link:||http://hdl.handle.net/10197/3780||Date:||Sep-2010||Abstract:||The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and di-hydroxylated metabolites were detected using gas chromatography-mass spectrometry and fluorine-19 nuclear magnetic resonance spectroscopy, and the major metabolite 4’-hydroxyflurbiprofen was isolated by preparative HPLC. C. elegans DSM 1908 and C. blakesleeana DSM 1906 also produced a phase II (conjugated) metabolite, which was identified as the sulfated drug via deconjugation experiments.||Funding Details:||Other funder||Type of material:||Journal Article||Publisher:||American Society for Microbiology||Copyright (published version):||2010 American Society for Microbiology||Keywords:||Fluorine||Subject LCSH:||Anti-inflammatory agents
|DOI:||10.1128/AEM.01027-10||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Biomolecular and Biomedical Science Research Collection|
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