Biotransformation of flurbiprofen by Cunninghamella species

Files in This Item:
File Description SizeFormat 
AEMTMP-02444-10_1.pdf172.99 kBAdobe PDFDownload
Title: Biotransformation of flurbiprofen by Cunninghamella species
Authors: Amadio, Jessica
Gordon, Katherine
Murphy, Cormac D.
Permanent link: http://hdl.handle.net/10197/3780
Date: Sep-2010
Abstract: The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and di-hydroxylated metabolites were detected using gas chromatography-mass spectrometry and fluorine-19 nuclear magnetic resonance spectroscopy, and the major metabolite 4’-hydroxyflurbiprofen was isolated by preparative HPLC. C. elegans DSM 1908 and C. blakesleeana DSM 1906 also produced a phase II (conjugated) metabolite, which was identified as the sulfated drug via deconjugation experiments.
Funding Details: Other funder
Type of material: Journal Article
Publisher: American Society for Microbiology
Copyright (published version): 2010 American Society for Microbiology
Keywords: Fluorine
Subject LCSH: Anti-inflammatory agents
Biotransformation (Metabolism)
Mucorales
DOI: 10.1128/AEM.01027-10
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection

Show full item record

SCOPUSTM   
Citations 20

20
Last Week
1
Last month
checked on Jun 22, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.