Biotransformation of fluorobiphenyl by Cunninghamella elegans
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|Title:||Biotransformation of fluorobiphenyl by Cunninghamella elegans||Authors:||Amadio, Jessica
Murphy, Cormac D.
|Permanent link:||http://hdl.handle.net/10197/3782||Date:||2010||Abstract:||The fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the culture supernatants with a variety of analytical techniques. 4-Fluorobiphenyl was principally transformed to 4-fluoro-4′-hydroxybiphenyl, but other mono- and dihydroxylated compounds were detected in organic extracts by gas chromatography–mass spectrometry. Additionally, fluorinated water-soluble products were detected by 19F NMR and were identified as sulphate and β-glucuronide conjugates. Other fluorobiphenyls (2-fluoro-, 4,4′-difluoro- and 2,3,4,5,6-pentafluoro-biphenyl) were catabolised by C. elegans, yielding mono- and dihydroxylated products, but phase II metabolites were detected from 4,4′-difluorobiphenyl only.||Funding Details:||Other funder||Type of material:||Journal Article||Publisher:||Springer||Copyright (published version):||2009 Springer-Verlag||Keywords:||Fluorine;Biphenyl;Metabolism;F-19 NMR||Subject LCSH:||Fluorine
|DOI:||10.1007/s00253-009-2346-4||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Biomolecular and Biomedical Science Research Collection|
CSCB Research Collection
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