Biotransformation of fluorobiphenyl by Cunninghamella elegans

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Title: Biotransformation of fluorobiphenyl by Cunninghamella elegans
Authors: Amadio, Jessica
Murphy, Cormac D.
Permanent link: http://hdl.handle.net/10197/3782
Date: 2010
Abstract: The fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the culture supernatants with a variety of analytical techniques. 4-Fluorobiphenyl was principally transformed to 4-fluoro-4′-hydroxybiphenyl, but other mono- and dihydroxylated compounds were detected in organic extracts by gas chromatography–mass spectrometry. Additionally, fluorinated water-soluble products were detected by 19F NMR and were identified as sulphate and β-glucuronide conjugates. Other fluorobiphenyls (2-fluoro-, 4,4′-difluoro- and 2,3,4,5,6-pentafluoro-biphenyl) were catabolised by C. elegans, yielding mono- and dihydroxylated products, but phase II metabolites were detected from 4,4′-difluorobiphenyl only.
Funding Details: Other funder
Type of material: Journal Article
Publisher: Springer
Copyright (published version): 2009 Springer-Verlag
Keywords: Fluorine;Biphenyl;Metabolism;F-19 NMR
Subject LCSH: Fluorine
Biphenyl compounds
Biotransformation (Metabolism)
Mucorales
DOI: 10.1007/s00253-009-2346-4
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection
CSCB Research Collection

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