Biotransformation of fluorobiphenyl by Cunninghamella elegans

DC FieldValueLanguage
dc.contributor.authorAmadio, Jessica-
dc.contributor.authorMurphy, Cormac D.-
dc.date.accessioned2012-09-04T15:59:46Z-
dc.date.available2012-09-04T15:59:46Z-
dc.date.copyright2009 Springer-Verlagen
dc.date.issued2010-
dc.identifier.citationApplied Microbiology and Biotechnologyen
dc.identifier.urihttp://hdl.handle.net/10197/3782-
dc.description.abstractThe fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the culture supernatants with a variety of analytical techniques. 4-Fluorobiphenyl was principally transformed to 4-fluoro-4′-hydroxybiphenyl, but other mono- and dihydroxylated compounds were detected in organic extracts by gas chromatography–mass spectrometry. Additionally, fluorinated water-soluble products were detected by 19F NMR and were identified as sulphate and β-glucuronide conjugates. Other fluorobiphenyls (2-fluoro-, 4,4′-difluoro- and 2,3,4,5,6-pentafluoro-biphenyl) were catabolised by C. elegans, yielding mono- and dihydroxylated products, but phase II metabolites were detected from 4,4′-difluorobiphenyl only.en
dc.description.sponsorshipOther funderen
dc.language.isoenen
dc.publisherSpringeren
dc.relation.requiresCSCB Research Collectionen
dc.rightsThe final publication is available at www.springerlink.comen
dc.subjectFluorineen
dc.subjectBiphenylen
dc.subjectMetabolismen
dc.subjectF-19 NMRen
dc.subject.lcshFluorineen
dc.subject.lcshBiphenyl compoundsen
dc.subject.lcshBiotransformation (Metabolism)en
dc.subject.lcshMucoralesen
dc.titleBiotransformation of fluorobiphenyl by Cunninghamella elegansen
dc.typeJournal Articleen
dc.internal.availabilityFull text availableen
dc.statusPeer revieweden
dc.identifier.volume86en
dc.identifier.issue1en
dc.identifier.startpage345en
dc.identifier.endpage351en
dc.identifier.doi10.1007/s00253-009-2346-4-
dc.neeo.contributorAmadio|Jessica|aut|-
dc.neeo.contributorMurphy|Cormac D.|aut|-
dc.description.othersponsorshipEPAen
dc.internal.rmsid134289184
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:Biomolecular and Biomedical Science Research Collection
CSCB Research Collection
Files in This Item:
File Description SizeFormat 
FBph manuscript revision.doc946 kBMicrosoft WordDownload
Show simple item record

SCOPUSTM   
Citations 20

19
Last Week
0
Last month
checked on Mar 21, 2019

Page view(s) 10

192
checked on May 25, 2018

Download(s) 10

766
checked on May 25, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.