Simulation of cortico-basal ganglia oscillations and their suppression by closed loop deep brain stimulation

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Title: Simulation of cortico-basal ganglia oscillations and their suppression by closed loop deep brain stimulation
Authors: Grant, Peadar F.
Lowery, Madeleine M.
Permanent link: http://hdl.handle.net/10197/3847
Date: 8-Jun-2012
Abstract: A new model of deep brain stimulation is presented that integrates volume conduction effects with a neural model of pathological beta-band oscillations in the cortico-basal ganglia network. The model is used to test the clinical hypothesis that closed-loop control of the amplitude of DBS may be possible, based on the average rectified value of beta-band oscillations in the local field potential. Simulation of closed-loop high-frequency Deep Brain Stimulation was shown to yield energy savings, with the magnitude of the energy saved dependent on the strength of coupling between the subthalamic nucleus and the remainder of the cortico-basal ganglia network. When closed-loop DBS was applied to a strongly coupled cortico-basal ganglia network, the stimulation energy delivered over a 480 s period was reduced by up to 42 %. Greater energy reductions were observed for weakly coupled networks, as the stimulation amplitude reduced to zero once the initial desynchronization had occurred. The results provide support for the application of closed-loop highfrequency DBS based on electrophysiological biomarkers.
Type of material: Journal Article
Publisher: IEEE
Copyright (published version): 2011 IEEE
Keywords: Closed-loop deep brain stimulationComputational model
Subject LCSH: Brain stimulation
Computer simulation
DOI: 10.1109/TNSRE.2012.2202403
Language: en
Status of Item: Peer reviewed
Appears in Collections:Electrical and Electronic Engineering Research Collection

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